If and how neurons remodel their connections after CNS injury critically influences recovery
of function. Here, we investigate the role of the growth‐initiating transcription factor STAT3 …

Axonal regeneration after spinal cord injury (SCI) is intrinsically and extrinsically inhibited by
multiple factors. One major factor contributing to intrinsic regeneration failure is the inability …

Sensory axons in the adult spinal cord do not regenerate after injury. This is essentially
because of inhibitory components in the damaged CNS, such as myelin-associated …

Axon regeneration after spinal cord injury (SCI) is limited by both a decreased intrinsic ability
of neurons to grow axons and the growth-hindering effects of extrinsic inhibitory molecules …

The limited rewiring of the corticospinal tract (CST) only partially compensates the lost
functions after stroke, brain trauma and spinal cord injury. Therefore it is important to …

The corticospinal tract (CST) can become damaged after spinal cord injury or stroke,
resulting in weakness or paralysis. Repair of the damaged CST is limited because mature …

Background Injuries to the spinal cord often result in severe functional deficits that, in case of
incomplete injuries, can be partially compensated by axonal remodeling. The corticospinal …

In the peripheral nervous system (PNS), damaged axons regenerate successfully, whereas
axons in the CNS fail to regrow. In neurons of the dorsal root ganglia (DRG), which extend …

The remodeling of supraspinal axonal circuits mediates functional recovery after spinal cord
injury. This process critically depends on the selection of appropriate synaptic connections …

Spinal cord injury (SCI) lesions present diverse challenges for repair strategies.
Anatomically complete injuries require restoration of neural connectivity across lesions …