A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese

L Yang, B Liu, B Huang, J Deng, H Li… - Human molecular …, 2013 - academic.oup.com
WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that has been
reported to lose function due to genetic alterations in several cancers. WWOX maps to the …

The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern Chinese populations

D Huang, F Qiu, L Yang, Y Li, M Cheng… - Molecular …, 2013 - Wiley Online Library
The WW domain‐containing oxidoreductase (WWOX) gene is an identified tumor
suppressor gene, of which several single nucleotide polymorphisms have been reported to …

Deletion and mutation of WWOX exons 6–8 in human non-small cell lung cancer

Z Yulong, X Yongjian, Z Zhenxiang - Journal of Huazhong University of …, 2005 - Springer
To examine the deletion and point mutation of WWOX (WW domain containing
oxidoreductase) exons 6–8 in human non-small cell lung cancer and their possible …

Association study of a functional copy number variation in the WWOX gene with risk of gliomas among Chinese people

K Yu, J Fan, X Ding, CY Li, J Wang… - … journal of cancer, 2014 - Wiley Online Library
Gliomas represents more than 80% of all malignant brain tumors. However, the etiology still
remains largely unknown. Human WW domain‐containing oxidoreductase (WWOX), which …

WWOX gene may contribute to progression of non-small-cell lung cancer (NSCLC)

O Baykara, A Demirkaya, K Kaynak, S Tanju, A Toker… - Tumor Biology, 2010 - Springer
Lung cancer is the most common cause of cancer-related death worldwide and, like many
other cancers, is affected by different genetic, epigenetic, and environmental factors. The …

Decreased expression of WWOX in the development of esophageal squamous cell carcinoma

W Guo, G Wang, Y Dong, Y Guo… - Molecular …, 2013 - Wiley Online Library
The WW domain‐containing oxidoreductase (WWOX) gene, located on chromosome 16q23.
3–24.1 in the region recognized as the common fragile site FRA16D is considered to be a …

Genetic and epigenetic alterations of WWOX in the development of gastric cardia adenocarcinoma

W Guo, Z Dong, Y Dong, Y Guo… - Environmental and …, 2013 - Wiley Online Library
WWOX is a tumor suppressor gene that maps to the common fragile site FRA16D and is
involved in carcinogenesis and cancer progression in many different carcinomas. Reduced …

[HTML][HTML] Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk

HL Cheng, YF Liu, CW Su, SC Su, MK Chen, SF Yang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
In Taiwan, oral cancer is the fourth leading cancer in males and is associated with exposure
to environmental carcinogens. WW domain-containing oxidoreductase (WWOX), a tumor …

[HTML][HTML] Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk

HL Lee, HL Cheng, YF Liu, MC Chou, SF Yang… - PloS one, 2017 - journals.plos.org
Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors
worldwide. Human WW domain-containing oxidoreductase (WWOX) gene has been …

Targeted deletion of Wwox reveals a tumor suppressor function

RI Aqeilan, F Trapasso, S Hussain… - Proceedings of the …, 2007 - National Acad Sciences
The WW domain-containing oxidoreductase (WWOX) spans the second most common
fragile site of the human genome, FRA16D, located at 16q23, and its expression is altered in …