Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders,
and neurodegenerative disease. There is emerging evidence that interventions that improve …

The rise in incidence of age‐related cognitive impairment is a global health concern. Ageing
is associated with a number of changes in the brain that, collectively, contribute to the …

The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed
against this burgeoning segment of the population is evidence that nonpathological aging is …

Aging is a physiological process that can develop without the appearance of concurrent
diseases. However, very frequently, older people suffer from memory loss and an …

Cognitive decline in elderly people often derives from the interaction between aging-related
changes and age-related diseases and covers a large spectrum of clinical manifestations …

Background Ageing is a highly complex process marked by a temporal cascade of events,
which promote alterations in the normal functioning of an individual organism. The triggers …

The onset of age-related neurodegenerative diseases superimposed on a declining nervous
system could enhance the motor and cognitive behavioral deficits that normally occur in …

The worldwide burden of dementia is immense, and set to increase to unprecedented levels
in the coming decades, due to population aging. In the absence of disease-modifying …

Alzheimer's disease (AD) is a type of incurable neurodegenerative disease that is
characterized by the accumulation of amyloid-β (Aβ; plaques) and tau hyperphosphorylation …

As people age they become increasingly susceptible to chronic and extremely debilitating
brain diseases. The precise cause of the neuronal degeneration underlying these disorders …