5-Fluorouracil (5-FU) is a chemotherapy drug widely used to treat a range of cancer types,
despite the recurrence of adverse reactions. Therefore, information on its side effects when …

Fluorouracil (5-FU) is the most frequently prescribed anti-tumor drug, but has been reported
to result in intestinal injury. Although some progress has been made in understanding the …

Certain chemotherapeutic agents subject cells to oxidative stress, thereby promoting
adverse effects. However, the molecular machinery governing 5‐fluorouracil (5‐FU) …

5-Fluorouracil (5-FU) is a pyrimidine analog widely used for the treatment of various
cancers, but often causes hepatic damage in clinical practice. In this study, we examined the …

Background: The goal of this study was to develop an animal model of intestinal injury
induced by 5-fluorouracil (5-FU) in pigs. Methods: Six domestic pigs were used as control …

Selective protection of the normal host tissues from the toxic effects of anticancer agents
would allow the use of higher, probably more effective, doses of the drugs. It has been …

Antimetabolites are a class of effective anticancer drugs interfering in essential biochemical
processes. 5-Fluorouracil (5-FU) and its prodrug Capecitabine are widely used in the …

Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)–treated cancer
patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in …

Thymoquinone (TQ) is one of the components extracted from Nigella sativa seeds and has
antioxidant, anti-inflammatory, and anticancer effects. We evaluated the effect of TQ on 5 …

5-Fluorouracil is one of the most commonly used anticancer drugs for the treatment of
various types of cancer but has potential adverse effects such as intestinal mucositis, renal …