Theragnostics is a promising approach that integrates diagnostics and therapeutics into a
single personalized strategy. To conduct effective theragnostic studies, it is essential to …

Oxidative stress and reactive oxygen species (ROS) are central to many physiological and
pathophysiological processes. However, due to multiple technical challenges, it is hard to …

Objective Energy metabolism is challenged upon nutrient stress, eventually leading to a
variety of metabolic diseases that represent a major global health burden. Methods Here, we …

Mitochondria are the organelles producing most of the energy and play important roles in a
variety of biochemical functions in human cells. Mitochondrial defects can cause ATP …

Mitochondrial metabolism links energy production to other essential cellular processes such
as signaling, cellular differentiation, and apoptosis. In addition to producing adenosine …

Mitochondrial activities are linked directly or indirectly to all cellular functions in aerobic
eukaryotes. Omics methods enable new approaches to study functional organization of …

Until recently restricted to hereditary mitochondrial diseases, mitochondrial dysfunction is
now recognized as a key player and strategic factor in the pathophysiological of many …

It is now becoming clear that human metabolism is extremely plastic and varies substantially
between healthy individuals. Understanding the biochemistry that underlies this physiology …

Under normal conditions, the cellular redox status is maintained in a steady state by
reduction and oxidation processes. These redox alterations in the cell are mainly sensed by …

High-throughput technologies for genomics, transcriptomics, proteomics, and metabolomics,
and integrative analysis of these data, enable new, systems-level insights into disease …