Engagement of the CD3/T cell antigen receptor complex on small, resting T cells is
insufficient to trigger cell-mediated cytotoxicity or to induce a proliferative response. In the …

B7/BB1 is a membrane differentiation antigen expressed on activated B cells, macrophages,
and dendritic cells that binds to a counter-receptor, CD28, expressed on T lymphocytes and …

Small, resting human peripheral blood T cells are able to mediate anti-CD3 redirected lysis
against murine P815 cells transfected with human B7, a ligand of CD28. We demonstrate …

Activation via the T lymphocyte cell surface molecule CD28 provides a potent amplification
signal for interleukin 2 (IL-2) production in several in vitro systems. The B lymphocyte …

A successful immune response requires intercellular contact between T and B lymphocytes.
We recently showed that CD28, a T cell surface protein that regulates an activation pathway …

Occupancy of the T-cell receptor complex does not appear to be a sufficient stimulus to
induce a T-cell-mediated immune response. Increasing evidence suggests that cognate cell …

Activation of a primary T-lymphocyte response requires additional signals apart from
interaction of the T-cell receptor (TcR)/CD3 complex with major histocompatibility complex …

B7-DC is a recently discovered member of the B7 family that binds to PD-1 and is selectively
expressed by dendritic cells (DCs). It has been shown to either costimulate or inhibit T cell …

The specificity of T lymphocyte activation is determined by engagement of the T cell receptor
(TCR) by peptide/major histocompatibility complexes expressed on the antigen-presenting …

The differentiation of CD4+ T cells into a Th1 vs Th2 phenotype profoundly influences the
outcome of autoimmune and infectious diseases. B7 costimulation has been shown to affect …