Increasing role of the cancer chemotherapeutic doxorubicin in cellular metabolism
AM Meredith, CR Dass - Journal of Pharmacy and …, 2016 - academic.oup.com
Objectives The use of doxorubicin, a drug utilised for many years to treat a wide variety of
cancers, has long been limited due to the significant toxicity that can occur not only during …
cancers, has long been limited due to the significant toxicity that can occur not only during …
Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells
RE Nicoletto, CM Ofner III - Cancer Chemotherapy and Pharmacology, 2022 - Springer
Doxorubicin (DOX) is a chemotherapeutic agent frequently used for the treatment of a variety
of tumor types, such as breast cancer. Despite the long history of DOX, the mechanistic …
of tumor types, such as breast cancer. Despite the long history of DOX, the mechanistic …
Possibilities to increase the effectiveness of doxorubicin in cancer cells killing
V Hanušová, I Boušová, L Skálová - Drug metabolism reviews, 2011 - Taylor & Francis
Anthracycline antibiotic doxorubicin (DOX) belongs among the most important
antineoplastics used in cancer therapy. Unfortunately, its cytostatic effect in therapeutic …
antineoplastics used in cancer therapy. Unfortunately, its cytostatic effect in therapeutic …
Dose-and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells
R Lüpertz, W Wätjen, R Kahl, Y Chovolou - Toxicology, 2010 - Elsevier
The cytostatic drug doxorubicin is a well-known chemotherapeutic agent which is used in
treatment of a wide variety of cancers. A key factor in the response of cancer cells to …
treatment of a wide variety of cancers. A key factor in the response of cancer cells to …
A correlation between cytotoxicity and reductase-mediated metabolism in cell lines treated with doxorubicin and daunorubicin
OS Bains, A Szeitz, JM Lubieniecka, GE Cragg… - … of Pharmacology and …, 2013 - ASPET
The role of metabolism in daunorubicin (DAUN)-and doxorubicin (DOX)-associated toxicity
in cancer patients is dependent on whether the parent drugs or major metabolites …
in cancer patients is dependent on whether the parent drugs or major metabolites …
Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems
O Tacar, P Sriamornsak, CR Dass - Journal of pharmacy and …, 2013 - academic.oup.com
Objectives The frontline drug doxorubicin has been used for treating cancer for over 30
years. While providing a cure in select cases, doxorubicin causes toxicity to most major …
years. While providing a cure in select cases, doxorubicin causes toxicity to most major …
A comprehensive review on time-tested anticancer drug doxorubicin
S Sritharan, N Sivalingam - Life sciences, 2021 - Elsevier
Doxorubicin or Adriamycin, is one of the most widely used chemotherapeutic drug for
treating a myriad of cancers. It induces cell death through multiple intracellular targets …
treating a myriad of cancers. It induces cell death through multiple intracellular targets …
Doxorubicin: An overview of the anti-cancer and chemoresistance mechanisms
I Micallef, B Baron - 2020 - um.edu.mt
Cancer remains one of the highest leading causes of morbidity and mortality worldwide.
Anthracyclines, specifically Doxorubicin (DOX), have been used for the past three decades …
Anthracyclines, specifically Doxorubicin (DOX), have been used for the past three decades …
Doxorubicin targets multiple players: a new view of an old problem
Anthracycline cardiotoxicity remains a serious problem in paediatric and adult cancer
survivors, and the advancement of cardio-oncology is a necessary step for an effective care …
survivors, and the advancement of cardio-oncology is a necessary step for an effective care …
Toxic effects and molecular mechanism of doxorubicin on different organs–an update
K Renu, LP Pureti, B Vellingiri… - Toxin …, 2022 - Taylor & Francis
Doxorubicin is an extensively used anti-neoplastic drug used for solid and hematogenous
cancer since the 1950s, and its usage is limited due to its toxic effects upon various organs …
cancer since the 1950s, and its usage is limited due to its toxic effects upon various organs …