Heart failure (HF) with preserved ejection fraction (HFpEF) is present in about 50% of HF
patients. Atrial remodeling is common in HFpEF and associated with increased mortality. We …

Aims Atrial contractile dysfunction is associated with increased mortality in heart failure (HF).
We have shown previously that a metabolic syndrome-based model of HFpEF and a model …

Metabolic syndrome-mediated heart failure with preserved ejection fraction (HFpEF) is
commonly accompanied by left atrial (LA) cardiomyopathy, significantly affecting morbidity …

Hypertensive heart disease (HHD) can cause left ventricular (LV) hypertrophy and heart
failure (HF). It is unclear, though, which factors may contribute to the transition from …

Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular diseases that often
co-exist. Animal models have suggested complex AF-promoting atrial structural, electrical …

Background Atrial fibrillation (AF) is often preceded by underlying cardiac diseases causing
ventricular pressure overload. Objective It was our aim to investigate the progression of atrial …

In the United States, only 2 major cardiovascular disorders are increasing in prevalence:
heart failure (HF) and atrial fibrillation (AF), representing 2 enormous public health …

Congestive heart failure (CHF) leads to atrial structural remodelling and increased
susceptibility to atrial fibrillation. The underlying molecular mechanisms are poorly …

Aims We sought to define the underlying mechanisms for atrial fibrillation (AF) during
chronic heart failure (HF). Methods and results Preliminary studies showed that 4 months of …

Heart failure (HF) causes complex, chronic changes in atrial structure and function, which
can cause substantial electrophysiological remodeling and predispose the individual to …