Microbial metabolites play an important role in regulating intestinal homeostasis and
immune responses. Propofol is a common anesthetic in clinic, but it is not clear whether it …

Under normal circumstances, the gut microbiota, host, and external environment establish a
dynamic ecological balance and maintain human health. Once this balance is broken, the …

In recent years, more and more attention has been paid to intestinal microbiome. Almost all
operations will go through the anesthesia process, but it is not clear whether the intervention …

The link between drug‐metabolizing enzymes and gut microbiota is well established. In
particular, hepatic cytochrome P450 (CYP) 3A activities are presumed to be affected by gut …

Background: Propofol inhibits fatty acid oxidation and induces mitochondrial deficiency, a
possible mechanism involved in propofol infusion syndrome. This study investigated how …

Sepsis is the dysregulated host response to an infection which leads to life-threatening
organ dysfunction. Metabolomic profiling in bio-fluid or tissue is vital for elucidating the …

Abstract Objective: Propofol (2, 6-diisopropylphenol) is widely used for anesthetic induction
as well as for chronic sedation in intensive care units. In this study, we investigated the …

Low-molecular-weight metabolites produced by the intestinal microbiome play a direct role
in health and disease. However, little is known about the ability of the colon to absorb these …

Purpose To study the effect of hypoxia and hyperoxia on the pharmacokinetics of propofol
emulsion, hepatic blood flow and arterial ketone body ratio in the rabbit. Methods Twenty …

Opioids such as morphine have many beneficial properties as analgesics, however, opioids
may induce multiple adverse gastrointestinal symptoms. It has been recently demonstrated …