Abstract Main conclusions The 4-coumarate-CoA ligases (4CL) contribute in channelizing
flux of different phenylpropanoid biosynthetic pathways. Expression of 4CL is optimized at …

Plant phenylpropanoids represent a large group of secondary metabolites which have
played an important role in terrestrial plant life, beginning with the evolution of land plants …

The enzyme 4‐coumarate: CoA ligase (4CL) plays a key role in channelling carbon flow into
diverse branch pathways of phenylpropanoid metabolism which serve important functions in …

coumarate: CoA ligase (4CL), the last enzyme of the general phenylpropanoid pathway,
provides precursors for the biosynthesis of a large variety of plant natural products. 4 CL …

Coumarate: coenzyme A ligase (4CL; EC 6.2. 1.12) is a key enzyme in the phenylpropanoid
metabolic pathways for monolignol and flavonoid biosynthesis. 4CL has been much studied …

4-Coumarate: CoA ligase (4CL, EC6. 2.1. 12), located at the end of the phenylpropanoid
metabolic pathway, regulates the metabolic direction of phenylpropanoid derivatives and …

A recent in silico analysis revealed that the Arabidopsis genome has 14 genes annotated as
putative 4-coumarate: CoA ligase isoforms or homologues. Of these, 11 were selected for …

Summary Plant 4-coumarate: CoA ligase (4CL) serves as a central catalyst in the
phenylpropanoid pathway that provides precursors for numerous metabolites and regulates …

4-Coumarate: CoA ligase (4CL; EC 6.2. 1.12) has a pivotal role in the biosynthesis of plant
secondary compounds at the divergence point from general phenylpropanoid metabolism to …

The biosynthesis of lignin, flavonoids, and hydroxycinnamoyl esters share the first three
enzymatic steps of the phenylpropanoid pathway. The last shared step is catalyzed by 4 …