Merosin-deficient congenital muscular dystrophy type 1A (MDC1A) is a lethal muscle-
wasting disease that is caused by mutations in the LAMA2 gene, resulting in the loss of …

Merosin-deficient congenital muscular dystrophy type 1A (MDC1A) is a severe and fatal
muscle-wasting disease with no cure. MDC1A patients and the dyW−/− mouse model exhibit …

Laminin-211 is a cell-adhesion molecule that is strongly expressed in the basement
membrane of skeletal muscle. By binding to the cell surface receptors dystroglycan and …

Congenital muscular dystrophy (CMD) is a class of severe early-onset muscular dystrophies
affecting skeletal/cardiac muscles as well as the central nervous system (CNS). Laminin-α2 …

Merosin-deficient congenital muscular dystrophy 1A (MDC1A) is a devastating
neuromuscular disease that results in children being confined to a wheelchair, requiring …

Laminin-211 is a major constituent of the skeletal muscle basement membrane. It stabilizes
skeletal muscle and influences signal transduction events from the myomatrix to the muscle …

Several approaches to treat laminin α2 chain–deficient congenital muscular dystrophy
(MDC1A) in mouse models have been undertaken. Most have shown promising results in …

Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating
neuromuscular disease caused by mutations in the LAMA2 gene. These mutations result in …

Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease caused by
mutations in the gene encoding dystrophin. Loss of dystrophin results in reduced …

Laminins are large heterotrimers composed of the α, β and γ subunits with distinct tissue-
specific and developmentally regulated expression patterns. The laminin-α2 subunit …