With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …

Adverse neurologic outcome, including cerebral palsy, is a significant contributor to long-
term morbidity in preterm neonates. However, the mechanisms leading to brain injury in the …

Injury to the premature brain is a major contributor to infant mortality and morbidity, often
leading to mental retardation and sensory-motor impairment. The disease process is …

Children surviving preterm birth have a high risk of disability, particularly cognitive and
learning problems. There is extensive clinical and experimental evidence that disability is …

Preterm birth can be caused by intrauterine infection and maternal/fetal inflammatory
responses. Maternal inflammation (chorioamnionitis) is often followed by a systemic fetal …

The preterm newborn is at significant risk of neural injury and impaired neurodevelopment.
Infants with mild or no evidence of injury may also be at risk of altered brain development …

Inflammation is increasingly recognized as being a critical contributor to both normal
development and injury outcome in the immature brain. The focus of this Review is to …

Chorioamnionitis is a major cause of preterm birth and brain injury. Bacterial invasion of the
chorion and amnion, and/or the placenta, can lead to a fetal inflammatory response, which in …

Background Antenatal infection (ie, chorioamnionitis) is an important risk factor for adverse
neurodevelopmental outcomes after preterm birth. Destructive and developmental …

Preterm newborns are exposed to several risk factors for developing brain injury. Clinical
studies have suggested that the presence of intrauterine infection is a consistent risk factor …