The clinical characterization of the adult patient with depression aimed at personalization of management

M Maj, DJ Stein, G Parker, M Zimmerman… - World …, 2020 - Wiley Online Library
Depression is widely acknowledged to be a heterogeneous entity, and the need to further
characterize the individual patient who has received this diagnosis in order to personalize …

Personalized medicine for depression: can we match patients with treatments?

GE Simon, RH Perlis - American Journal of Psychiatry, 2010 - Am Psychiatric Assoc
Objective: Response to specific depression treatments varies widely among individuals.
Understanding and predicting that variation could have great benefits for people living with …

Personalized treatment of adult depression: medication, psychotherapy, or both? A systematic review

P Cuijpers, CF Reynolds III, T Donker, J Li… - Depression and …, 2012 - Wiley Online Library
Background Personalized medicine aims to identify which characteristics of an individual
predict the outcome of a specific treatment, in order to get a better match between the …

[HTML][HTML] Optimizing personalized management of depression: the importance of real‐world contexts and the need for a new convergence paradigm in mental health

CF Reynolds - World Psychiatry, 2020 - ncbi.nlm.nih.gov
In this issue of the journal, Maj et al1 have revisited a fundamental tenet of psychiatric
medicine, namely, that more precise clinical characterization of patients with depression will …

The clinical effectiveness of using a predictive algorithm to guide antidepressant treatment in primary care (PReDicT): an open-label, randomised controlled trial

M Browning, AC Bilderbeck, R Dias… - …, 2021 - nature.com
Depressed patients often do not respond to the first antidepressant prescribed, resulting in
sequential trials of different medications. Personalised medicine offers a means of reducing …

Abandoning personalization to get to precision in the pharmacotherapy of depression

RH Perlis - World Psychiatry, 2016 - Wiley Online Library
Effectiveness studies and analyses of naturalistic cohorts demonstrate that many patients
with major depressive disorder do not experience symptomatic remission with …

Predicting treatment outcome in depression: an introduction into current concepts and challenges

N Rost, EB Binder, TM Brückl - European Archives of Psychiatry and …, 2023 - Springer
Improving response and remission rates in major depressive disorder (MDD) remains an
important challenge. Matching patients to the treatment they will most likely respond to …

Personalized psychotherapy for adult depression: a meta-analytic review

P Cuijpers, DD Ebert, C Acarturk, G Andersson… - Behavior Therapy, 2016 - Elsevier
Personalized medicine is aimed at identifying which characteristics of an individual predict
the outcome of a specific treatment, in order to get a better match between the individual and …

Psychotherapies for depression: a network meta‐analysis covering efficacy, acceptability and long‐term outcomes of all main treatment types

P Cuijpers, S Quero, H Noma, M Ciharova… - World …, 2021 - Wiley Online Library
The effects of psychotherapies for depression have been examined in several hundreds of
randomized trials, but no recent network meta‐analysis (NMA) has integrated the results of …

The symptom‐specific efficacy of antidepressant medication vs. cognitive behavioral therapy in the treatment of depression: Results from an individual patient data …

L Boschloo, E Bekhuis, ES Weitz, M Reijnders… - World …, 2019 - Wiley Online Library
A recent individual patient data meta‐analysis showed that antidepressant medication is
slightly more efficacious than cognitive behavioral therapy (CBT) in reducing overall …