Hot melt extrusion (HME) is a common unit operation. It is broadly applicable in the
pharmaceutical industry and can be implemented in a continuous manufacturing line …

Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …

Pharmaceutical hot-melt extrusion (HME) has been explored and studied in the last few
decades, by both industrial and academic investigators, because of its potential of rendering …

The high numbers of active pharmaceutical ingredients (APIs) within pharmaceutical
pipelines that possess limited bioavailability is a major concern for the pharmaceutical …

Hot-melt extrusion (HME) is a promising technology for the production of new chemical
entities in the developmental pipeline and for improving products already on the market. In …

Context: Manufacturing solid low-dose pharmaceutical products has always the
homogeneity challenge. In continuous manufacturing, there is the additional challenge of …

Abstract Hot Melt Extrusion (HME) is a continuous solvent-and dust-free manufacturing
process that requires the use of only a limited number of excipients and low-cost …

Melt extrusion (ME) over recent years has found widespread application as a viable drug
delivery option in the drug development process. ME applications include taste masking …

Introduction: Hot-melt extrusion (HME) technology is applied successfully in the plastic,
rubber and food industry. HME has also emerged as an important technology for drug …

The aim of this study was to investigate the efficiency of hydrophilic polymers to enhance the
dissolution rate of poorly water-soluble active pharmaceutical ingredients (APIs) processed …