4-Hydroxynonenal (4-HNE) is one of the major end products of lipid peroxidation. It has
been widely accepted that 4-HNE can induce oxidative stress, implicating into extensive …

Background NF-E2-related factor 2 (NRF2) regulates a battery of antioxidative and phase II
drug metabolizing/detoxifying genes through binding to the antioxidant response elements …

This study investigates the roles of ROS overproduction and MAPK signaling pathways in
the induction of unfolded protein response (UPR) and the expression of Phase II enzymes in …

Recent studies indicate that 4‐hydroxy‐trans‐2‐nonenal (HNE), a major oxidative stress
triggered lipid peroxidation‐derived aldehyde, plays a critical role in the pathophysiology of …

Reactive intermediates produced during oxidative stress are believed to contribute to the
development and progression of a variety of age-related diseases. 4-Hydroxy-2-nonenal …

Oxidative stress plays an important role in neuronal cell death associated with many
different neurodegenerative conditions, and it is reported that 4-hydroxynonenal (HNE), an …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive
degeneration of dopaminergic neurons in the substantia nigra. Oxidative stress has been …

Natural compounds containing phenoxyl groups and/or Michael acceptor units appear to
possess antioxidant and cytoprotective properties. The ginger principal constituent 6 …

Abstract Glutathione-S-Transferases (GSTs) have primarily been thought to be xenobiotic
metabolizing enzymes that protect cells from toxic drugs and environmental electrophiles …

Large-scale clinical studies have shown that n-3 polyunsaturated fatty acids (n-3 PUFAs)
such as eicosapentaenoic and docosahexaenoic acids reduce cardiovascular events …