Phenotypic and genomic insights into mutant with high nattokinase-producing activity induced by carbon ion beam irradiation of Bacillus subtilis
Y Sheng, S Zhang, X Li, S Wang, T Liu, C Wang… - International Journal of …, 2024 - Elsevier
Nattokinase (NK) is found in fermented foods and has high fibrinolytic activity, which makes
it promising for biological applications. In this study, a mutant strain (Bacillus subtilis ZT-S1 …
it promising for biological applications. In this study, a mutant strain (Bacillus subtilis ZT-S1 …
Genomic and transcriptomic analysis of Bacillus subtilis JNFE1126 with higher nattokinase production through ultraviolet combined 60Co-γ ray mutagenesis
Y Wang, J Wang, X Zhang, Y Tong, R Yang - Lwt, 2021 - Elsevier
Nattokinase is a serine protease which is produced by Bacillus subtilis and exhibits vigorous
fibrinolytic activity. Nattokinase is useful for preventing and treating thromboembolic …
fibrinolytic activity. Nattokinase is useful for preventing and treating thromboembolic …
[HTML][HTML] High-level extracellular production of recombinant nattokinase in Bacillus subtilis WB800 by multiple tandem promoters
Z Liu, W Zheng, C Ge, W Cui, L Zhou, Z Zhou - BMC microbiology, 2019 - Springer
Background Nattokinase (NK), which is a member of the subtilisin family, is a potent
fibrinolytic enzyme that might be useful for thrombosis therapy. Extensive work has been …
fibrinolytic enzyme that might be useful for thrombosis therapy. Extensive work has been …
Enhanced production of recombinant nattokinase in Bacillus subtilis by promoter optimization
SM Wu, C Feng, J Zhong, LD Huan - World Journal of Microbiology and …, 2011 - Springer
Nattokinase (NK) is a health product for the prevention and potential control of thrombosis
diseases. To explore the possibility of enhancing NK production in Bacillus subtilis by …
diseases. To explore the possibility of enhancing NK production in Bacillus subtilis by …
Comparative analysis of the transcriptome of Bacillus subtilis natto incubated in different substrates for nattokinase production
D Liu, Z Han, Z Hu, C Yu, Y Wang, J Tong, X Fang… - Process …, 2023 - Elsevier
Nattokinase (NK) is a serine protease to prevent and treat cardiovascular diseases, and
owns potential applications in the fields of food and medicine. However, the unclear …
owns potential applications in the fields of food and medicine. However, the unclear …
High and economical nattokinase production with acetoin as a useful byproduct from soybean milk and glucose
Z Xiao, J Shen, Y Li, Z Wang, Y Zhao, Y Chen… - Probiotics and …, 2022 - Springer
Nattokinase (NK) is a potent fibrinolytic enzyme with wide pharmaceutical and nutraceutical
applications. Safe and high NK-yielding strains are urgently needed. In this study, the best …
applications. Safe and high NK-yielding strains are urgently needed. In this study, the best …
High Cell Density Cultivation of A Recombinant Bacillus Subtilis for Nattokinase Production
J Zhang, Q Cui, B Qian, X Sun - 2020 - researchsquare.com
Background: Nattokinase (NK), a fibrinolytic enzyme, can be produced by culturing
recombinant Bacillus subtilis in Luria-Bertani broth in a shaking flask. For use as a …
recombinant Bacillus subtilis in Luria-Bertani broth in a shaking flask. For use as a …
Comparative genomic analyses of Bacillus subtilis strains to study the biochemical and molecular attributes of nattokinases
The present research work explores the Nattokinase (NK) producing capacity of five Bacillus
subtilis strains (MTCC 2616, MTCC 2756, MTCC 2451, MTCC 1427, and MTCC 7164) using …
subtilis strains (MTCC 2616, MTCC 2756, MTCC 2451, MTCC 1427, and MTCC 7164) using …
[HTML][HTML] Cloning and enhancing production of a detergent- and organic-solvent-resistant nattokinase from Bacillus subtilis VTCC-DVN-12-01 by using an eight-protease-gene …
TT Nguyen, TD Quyen, HT Le - Microbial cell factories, 2013 - Springer
Abstract Background Nattokinases/Subtilisins (EC 3.4. 21.62) belong to the second large
family of serine proteases, which gain significant attention and play important role in many …
family of serine proteases, which gain significant attention and play important role in many …
[HTML][HTML] Heterologous expression of nattokinase from B. subtilis natto using Pichia pastoris GS115 and assessment of its thrombolytic activity
Y Guangbo, S Min, S Wei, M Lixin, Z Chao, W Yaping… - BMC …, 2021 - Springer
Background Nattokinase is a fibrinolytic enzyme that has huge market value as a nutritional
supplement for health promotion. In order to increase nattokinase yields, fermentation …
supplement for health promotion. In order to increase nattokinase yields, fermentation …