[HTML][HTML] Galleria mellonella immune melanization is fungicidal during infection
DFQ Smith, Q Dragotakes, M Kulkarni… - Communications …, 2022 - nature.com
A key component of the insect immune response is melanin production, including within
nodules, or aggregations of immune cells surrounding microbes. Melanization produces …
nodules, or aggregations of immune cells surrounding microbes. Melanization produces …
Melanization is an important antifungal defense mechanism in Galleria mellonella hosts
DFQ Smith, Q Dragotakes, M Kulkarni, JM Hardwick… - bioRxiv, 2022 - biorxiv.org
A key component of insect immunity is melanin encapsulation of microbes. Melanization is
also a part of an immune process known as nodulation, which occurs when insect …
also a part of an immune process known as nodulation, which occurs when insect …
Reduced virulence of melanized Cryptococcus neoformans in Galleria mellonella
HC Eisenman, R Duong, H Chan, R Tsue… - Virulence, 2014 - Taylor & Francis
Fungal melanins are important in the virulence of many pathogenic fungi. In this study, we
examined the role of melanin in the interaction between Cryptococcus neoformans and the …
examined the role of melanin in the interaction between Cryptococcus neoformans and the …
[HTML][HTML] Melanization of Candida auris Is Associated with Alteration of Extracellular pH
Candida auris is a recently emerged global fungal pathogen, which causes life-threatening
infections, often in healthcare settings. C. auris infections are worrisome because the fungus …
infections, often in healthcare settings. C. auris infections are worrisome because the fungus …
The role of melanin in fungal pathogenesis for animal hosts
DFQ Smith, A Casadevall - Fungal physiology and immunopathogenesis, 2019 - Springer
Melanins are a class of pigments that are ubiquitous throughout biology. They play
incredibly diverse and important roles ranging from radiation protection to immune defense …
incredibly diverse and important roles ranging from radiation protection to immune defense …
[HTML][HTML] Fungal melanin and the mammalian immune system
S Liu, S Youngchim, D Zamith-Miranda, JD Nosanchuk - Journal of Fungi, 2021 - mdpi.com
Melanins are ubiquitous complex polymers that are commonly known in humans to cause
pigmentation of our skin. Melanins are also present in bacteria, fungi, and helminths. In this …
pigmentation of our skin. Melanins are also present in bacteria, fungi, and helminths. In this …
Sporothrix globosa melanin inhibits antigenpresentation by macrophages and enhances deep organ dissemination
Y Song, L Yao, Y Zhen, Y Cui, S Zhong, Y Liu… - Brazilian journal of …, 2021 - Springer
Melanin is a Sporothrix virulence factor that can inhibit the innate immune functions of
macrophages such as phagocytosis and killing. However, no data on melanin's influence on …
macrophages such as phagocytosis and killing. However, no data on melanin's influence on …
[HTML][HTML] Glyphosate inhibits melanization and increases susceptibility to infection in insects
Melanin, a black-brown pigment found throughout all kingdoms of life, has diverse biological
functions including UV protection, thermoregulation, oxidant scavenging, arthropod …
functions including UV protection, thermoregulation, oxidant scavenging, arthropod …
[HTML][HTML] A novel 43-kDa protein as a negative regulatory component of phenoloxidase-induced melanin synthesis
M Zhao, I Soderhall, JW Park, YG Ma, T Osaki… - Journal of Biological …, 2005 - ASBMB
The melanization reaction induced by activated phenoloxidase in arthropods is important in
the multiple host defense innate immune reactions, leading to the sequestration and killing …
the multiple host defense innate immune reactions, leading to the sequestration and killing …
Melanization of Cryptococcus neoformans Affects Lung Inflammatory Responses during Cryptococcal Infection
AJ Mednick, JD Nosanchuk… - Infection and immunity, 2005 - Am Soc Microbiol
The production of melanin pigments is associated with virulence for many microbes. Melanin
is believed to contribute to microbial virulence by protecting microbial cells from oxidative …
is believed to contribute to microbial virulence by protecting microbial cells from oxidative …