[HTML][HTML] Calcineurin Plays Key Roles in the Dimorphic Transition and Virulence of the Human Pathogenic Zygomycete Mucor circinelloides

SC Lee, A Li, S Calo, J Heitman - PLoS pathogens, 2013 - journals.plos.org
Many pathogenic fungi are dimorphic and switch between yeast and filamentous states. This
switch alters host-microbe interactions and is critical for pathogenicity. However, in …

A novel resistance pathway for calcineurin inhibitors in the human-pathogenic mucorales Mucor circinelloides

S Vellanki, RB Billmyre, A Lorenzen, M Campbell… - MBio, 2020 - Am Soc Microbiol
Mucormycosis is an emerging lethal fungal infection in immunocompromised patients.
Mucor circinelloides is a causal agent of mucormycosis and serves as a model system to …

Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host–pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides

SC Lee, A Li, S Calo, M Inoue, NK Tonthat… - Molecular …, 2015 - Wiley Online Library
Calcineurin plays essential roles in virulence and growth of pathogenic fungi and is a target
of the natural products FK 506 and C yclosporine A. In the pathogenic mucoralean fungus M …

Rapamycin Exerts Antifungal Activity In Vitro and In Vivo against Mucor circinelloides via FKBP12-Dependent Inhibition of Tor

RJ Bastidas, CA Shertz, SC Lee, J Heitman… - Eukaryotic …, 2012 - Am Soc Microbiol
The zygomycete Mucor circinelloides is an opportunistic fungal pathogen that commonly
infects patients with malignancies, diabetes mellitus, and solid organ transplants. Despite …

[HTML][HTML] RNAi-based functional genomics identifies new virulence determinants in mucormycosis

TA Trieu, MI Navarro-Mendoza, C Pérez-Arques… - PLoS …, 2017 - journals.plos.org
Mucorales are an emerging group of human pathogens that are responsible for the lethal
disease mucormycosis. Unfortunately, functional studies on the genetic factors behind the …

Drug-resistant epimutants exhibit organ-specific stability and induction during murine infections caused by the human fungal pathogen Mucor circinelloides

Z Chang, J Heitman - MBio, 2019 - Am Soc Microbiol
The environmentally ubiquitous fungus Mucor circinelloides is a primary cause of the
emerging disease mucormycosis. Mucor infection is notable for causing high morbidity and …

Identification and analysis of genes involved in the control of dimorphism in Mucor circinelloides (syn. racemosus)

AM Wolff, KF Appel, JB Petersen, U Poulsen… - FEMS yeast …, 2002 - academic.oup.com
Mucor circinelloides (syn. racemosus) is a non-pathogenic dimorphic fungus belonging to
the class of zygomycetes. We are developing a novel system for heterologous protein …

[HTML][HTML] Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides

Z Chang, RB Billmyre, SC Lee, J Heitman - PLoS Genetics, 2019 - journals.plos.org
Mucormycosis—an emergent, deadly fungal infection—is difficult to treat, in part because the
causative species demonstrate broad clinical antifungal resistance. However, the …

[HTML][HTML] Sporangiospore Size Dimorphism Is Linked to Virulence of Mucor circinelloides

CH Li, M Cervantes, DJ Springer, T Boekhout… - PLoS …, 2011 - journals.plos.org
Mucor circinelloides is a zygomycete fungus and an emerging opportunistic pathogen in
immunocompromised patients, especially transplant recipients and in some cases otherwise …

[HTML][HTML] Components of a new gene family of ferroxidases involved in virulence are functionally specialized in fungal dimorphism

MI Navarro-Mendoza, C Pérez-Arques, L Murcia… - Scientific reports, 2018 - nature.com
Mucormycosis is an emerging angio-invasive infection caused by Mucorales that presents
unacceptable mortality rates. Iron uptake has been related to mucormycosis, since serum …