Precise prediction of multiple anticancer drug efficacy using multi target regression and support vector regression analysis
GR Brindha, BS Rishiikeshwer, B Santhi… - Computer Methods and …, 2022 - Elsevier
Background and objectives The prediction of multiple drug efficacies using machine
learning prediction techniques based on clinical and molecular attributes of tumors is a new …
learning prediction techniques based on clinical and molecular attributes of tumors is a new …
Computational models for predicting anticancer drug efficacy: A multi linear regression analysis based on molecular, cellular and clinical data of oral squamous cell …
BM Robert, GR Brindha, B Santhi, G Kanimozhi… - Computer methods and …, 2019 - Elsevier
Background and objectives The computational prediction of drug responses based on the
analysis of multiple clinical features of the tumor will be a novel strategy for accomplishing …
analysis of multiple clinical features of the tumor will be a novel strategy for accomplishing …
Integrated drug response prediction models pinpoint repurposed drugs with effectiveness against rhabdomyosarcoma
B Baek, E Jang, S Park, SH Park, DR Williams… - Plos one, 2024 - journals.plos.org
Targeted therapies for inhibiting the growth of cancer cells or inducing apoptosis are
urgently needed for effective rhabdomyosarcoma (RMS) treatment. However, identifying …
urgently needed for effective rhabdomyosarcoma (RMS) treatment. However, identifying …
A performance evaluation of drug response prediction models for individual drugs
A Park, Y Lee, S Nam - Scientific Reports, 2023 - nature.com
Drug response prediction is important to establish personalized medicine for cancer therapy.
Model construction for predicting drug response (ie, cell viability half-maximal inhibitory …
Model construction for predicting drug response (ie, cell viability half-maximal inhibitory …
Drug sensitivity prediction framework using ensemble and multi-task learning
Radiation and hormone level targeted drug therapy are one of the most widely adopted
treatment options for different types of cancer. But, due to genetic variations, cancer patients …
treatment options for different types of cancer. But, due to genetic variations, cancer patients …
Machine learning model to predict oncologic outcomes for drugs in randomized clinical trials
Predicting oncologic outcome is challenging due to the diversity of cancer histologies and
the complex network of underlying biological factors. In this study, we determine whether …
the complex network of underlying biological factors. In this study, we determine whether …
A supervised machine-learning approach for the efficient development of a multi method (LC-MS) for a large number of drugs and subsets thereof: focus on oral …
Objectives Accumulating evidence argues for a more widespread use of therapeutic drug
monitoring (TDM) to support individualized medicine, especially for therapies where toxicity …
monitoring (TDM) to support individualized medicine, especially for therapies where toxicity …
Computational identification of multi-omic correlates of anticancer therapeutic response
LC Stetson, T Pearl, Y Chen, JS Barnholtz-Sloan - BMC genomics, 2014 - Springer
Background A challenge in precision medicine is the transformation of genomic data into
knowledge that can be used to stratify patients into treatment groups based on predicted …
knowledge that can be used to stratify patients into treatment groups based on predicted …
Predicting anti-cancer drug response by finding optimal subset of drugs
F Yassaee Meybodi, C Eslahchi - Bioinformatics, 2021 - academic.oup.com
Motivation One of the most difficult challenges in precision medicine is determining the best
treatment strategy for each patient based on personal information. Since drug response …
treatment strategy for each patient based on personal information. Since drug response …
kESVR: An ensemble model for drug response prediction in precision medicine using cancer cell lines gene expression
A Majumdar, Y Liu, Y Lu, S Wu, L Cheng - Genes, 2021 - mdpi.com
Background: Cancer cell lines are frequently used in research as in-vitro tumor models.
Genomic data and large-scale drug screening have accelerated the right drug selection for …
Genomic data and large-scale drug screening have accelerated the right drug selection for …