Precise prediction of multiple anticancer drug efficacy using multi target regression and support vector regression analysis

GR Brindha, BS Rishiikeshwer, B Santhi… - Computer Methods and …, 2022 - Elsevier
Background and objectives The prediction of multiple drug efficacies using machine
learning prediction techniques based on clinical and molecular attributes of tumors is a new …

Computational models for predicting anticancer drug efficacy: A multi linear regression analysis based on molecular, cellular and clinical data of oral squamous cell …

BM Robert, GR Brindha, B Santhi, G Kanimozhi… - Computer methods and …, 2019 - Elsevier
Background and objectives The computational prediction of drug responses based on the
analysis of multiple clinical features of the tumor will be a novel strategy for accomplishing …

Integrated drug response prediction models pinpoint repurposed drugs with effectiveness against rhabdomyosarcoma

B Baek, E Jang, S Park, SH Park, DR Williams… - Plos one, 2024 - journals.plos.org
Targeted therapies for inhibiting the growth of cancer cells or inducing apoptosis are
urgently needed for effective rhabdomyosarcoma (RMS) treatment. However, identifying …

A performance evaluation of drug response prediction models for individual drugs

A Park, Y Lee, S Nam - Scientific Reports, 2023 - nature.com
Drug response prediction is important to establish personalized medicine for cancer therapy.
Model construction for predicting drug response (ie, cell viability half-maximal inhibitory …

Drug sensitivity prediction framework using ensemble and multi-task learning

A Sharma, R Rani - International Journal of Machine Learning and …, 2020 - Springer
Radiation and hormone level targeted drug therapy are one of the most widely adopted
treatment options for different types of cancer. But, due to genetic variations, cancer patients …

Machine learning model to predict oncologic outcomes for drugs in randomized clinical trials

AV Schperberg, A Boichard, IF Tsigelny… - … journal of cancer, 2020 - Wiley Online Library
Predicting oncologic outcome is challenging due to the diversity of cancer histologies and
the complex network of underlying biological factors. In this study, we determine whether …

A supervised machine-learning approach for the efficient development of a multi method (LC-MS) for a large number of drugs and subsets thereof: focus on oral …

N Kehl, A Gessner, R Maas, MF Fromm… - Clinical Chemistry and …, 2024 - degruyter.com
Objectives Accumulating evidence argues for a more widespread use of therapeutic drug
monitoring (TDM) to support individualized medicine, especially for therapies where toxicity …

Computational identification of multi-omic correlates of anticancer therapeutic response

LC Stetson, T Pearl, Y Chen, JS Barnholtz-Sloan - BMC genomics, 2014 - Springer
Background A challenge in precision medicine is the transformation of genomic data into
knowledge that can be used to stratify patients into treatment groups based on predicted …

Predicting anti-cancer drug response by finding optimal subset of drugs

F Yassaee Meybodi, C Eslahchi - Bioinformatics, 2021 - academic.oup.com
Motivation One of the most difficult challenges in precision medicine is determining the best
treatment strategy for each patient based on personal information. Since drug response …

kESVR: An ensemble model for drug response prediction in precision medicine using cancer cell lines gene expression

A Majumdar, Y Liu, Y Lu, S Wu, L Cheng - Genes, 2021 - mdpi.com
Background: Cancer cell lines are frequently used in research as in-vitro tumor models.
Genomic data and large-scale drug screening have accelerated the right drug selection for …