A decline in long-term memory (LTM) formation is a common feature of the normal aging
process, which corresponds with abnormal expression of memory-related genes in the aged …

Aging weakens memory functions. Exposing healthy rodents or pathological rodent models
to environmental enrichment (EE) housing improves their cognitive functions by changing …

With advancing age, memory declines through different mechanisms including
dysregulation of expression of synaptic plasticity genes in hippocampus. Increasing …

Mounting evidence linking epigenetic regulation to memory-related synaptic plasticity raises
the possibility that altered chromatin modification dynamics might contribute to age …

The decline of brain function during aging is associated with epigenetic changes, including
DNA methylation. Lifestyle interventions can improve brain function during aging, but their …

An increasing number of studies show that an altered epigenetic landscape may cause
impairments in regulation of learning and memory-related genes within the aged …

In humans and rats, aging is associated with a progressive deterioration of spatial learning
and memory. These functional alterations are correlated with morphological and molecular …

As the human life span increases, the number of people suffering from cognitive decline is
rising dramatically. The mechanisms underlying age-associated memory impairment are …

A decline in learning and memory is a feature of the normal aging process and associated
with neurodegenerative diseases such as dementia and Alzheimer's disease. Moreover …

Epigenetic modifications of chromatin structure provide a mechanistic interface for gene–
environment interactions that impact the individualization of health trajectories across the …