The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase
that is activated by several ligands leading to the activation of diverse signaling pathways …

Epidemiological studies have established that many tumours occur in association with
persistent inflammation. One clear example of inflammation-related cancer is hepatocellular …

The liver displays an outstanding wound healing and regenerative capacity unmatched by
any other organ. This reparative response is governed by a complex network of …

Mice lacking the EGF receptor (EGFR) die between midgestation and postnatal day 20 with
various defects in neural and epithelial organs. Here, we generated mice carrying a floxed …

Hepatocarcinogenesis is a complex multistep process in which many different molecular
pathways have been implicated. Hepatocellular carcinoma (HCC) is refractory to …

Hepatocellular carcinoma (HCC) is a frequent cancer with limited treatment options and
poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic …

Epidermal growth factor receptor (EGFR) is conventionally known to play a crucial role in
hepatocyte proliferation, liver regeneration and is also associated with hepatocellular …

Epidermal growth factor receptor (EGFR) binds transforming growth factor α (TGF‐α) which
is mitogenic for hepatocytes. Diverse lines of evidence suggest that activation of the TGF …

BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is one of the most common cancer-
related causes of death worldwide. Due to very poor 5-year-survival new therapeutic …

Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer‐related
mortality in the United States. Because of the lack of viable treatment options for HCC …