Two faces of arbutin in hepatocellular carcinoma (HepG2) cells: Anticarcinogenic effect in high concentration and protective effect against cisplatin toxicity through its …

Ö Hazman, H Evin, MF Bozkurt, İH Ciğerci - Biologia, 2022 - Springer
Arbutin is one of the active substances frequently used as a skin whitening agent in cosmetic
products. Possible effects of arbutin on hepatocellular carcinoma (HepG2) cells and cisplatin …

The anticarcinogen activity of β-arbutin on MCF-7 cells: Stimulation of apoptosis through estrogen receptor-α signal pathway, inflammation and genotoxicity

Ö Hazman, A Sarıova, MF Bozkurt… - Molecular and Cellular …, 2021 - Springer
Arbutin is one of the active ingredients employed in cosmetics as a skin whitening agent. In
the present study, the possible effects of arbutin on breast cancer were determined with …

[HTML][HTML] The effect of arbutin on the expression of tumor suppressor P53, BAX/BCL-2 ratio and oxidative stress induced by tert-butyl hydroperoxide in fibroblast and …

S Ebadollahi, M Pouramir, E Zabihi… - Cell Journal …, 2021 - ncbi.nlm.nih.gov
Objective Arbutin (p-hydroxyphenyl-β-D-glucopyranoside) possesses beneficial functions
including antioxidant, anti-inflammatory, and anti-tumoral activities. Due to the important role …

[PDF][PDF] Cytoprotective effects of arbutin against tert-butyl hydroperoxid induced toxicity in Hep-G2 cell line

N Seyfizadeh, S Mahjoub, E Zabihi… - World Appl Sci …, 2012 - academia.edu
Arbutin has antioxidative properties with potential benefits in many diseases. In this study,
the cytoprotective and antioxidant effects of arbutin against t-BPH induced oxidative stress in …

[HTML][HTML] Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murine melanoma cells

L Jiang, D Wang, Y Zhang, J Li… - International …, 2018 - spandidos-publications.com
Arbutin, a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi,
possesses whitening and anticancer properties. The effects of arbutin on melanogenesis …

Arbutin exerts anticancer activity against rat C6 glioma cells by inducing apoptosis and inhibiting the inflammatory markers and P13/Akt/mTOR cascade

Z Yang, H Shi, A Chinnathambi… - … of biochemical and …, 2021 - Wiley Online Library
Gliomas are a type of brain cancer that occurs in the supporting glial cells of the brain. It is
highly malignant and accounts for 80% of brain tumors with high mortality and morbidity …

Toxicogenomics of A375 human malignant melanoma cells treated with arbutin

SL Cheng, RH Liu, JN Sheu, ST Chen… - Journal of biomedical …, 2007 - Springer
Although arbutin is a natural product and widely used as an ingredient in skin care products,
its effect on the gene expression level of human skin with malignant melanoma cells is rarely …

Decrease of intracellular ROS by arbutin is associated with apoptosis induction and downregulation of IL‐1β and TNF‐α in LNCaP; prostate cancer

H Safari, E Zabihi, M Pouramir… - Journal of Food …, 2020 - Wiley Online Library
Increased reactive oxygen species (ROS) along with inflammation are involved in the
prostate cancer (PCa). Therefore, this study was conducted to investigate the molecular …

Apigenin alleviates methotrexate-induced liver and kidney injury in mice

F Sahindokuyucu-Kocasari, Y Akyol… - Human & …, 2021 - journals.sagepub.com
Methotrexate (MTX) is a drug used in the treatment of various types of cancer and
inflammatory diseases, but its clinical use has been restricted due to its toxicity. Apigenin …

Role of metabolism by the human intestinal microflora in arbutin-induced cytotoxicity in HepG2 cell cultures

T Khanal, HG Kim, YP Hwang, MJ Kong… - Biochemical and …, 2011 - Elsevier
A possible role for metabolism by the human intestinal microflora in arbutin-induced
cytotoxicity was investigated using human hepatoma HepG2 cells. When the cytotoxic …