Impact of azole drugs on energetics, kinetics, and ligand migration pathways of CO photo-dissociation in bacterial flavohemoglobins

D Butcher, M Moussaoui, L Baciou, J Miksovska - RSC advances, 2020 - pubs.rsc.org
Flavohemoglobins (fHbs) are heme proteins found in prokaryotic and eukaryotic microbes.
They are involved in NO detoxification through an NO˙ dioxygenase mechanism. The N …

The key role of water in the dioxygenase function of Escherichia coli flavohemoglobin

DN Ferreiro, L Boechi, DA Estrin, MA Martí - Journal of inorganic …, 2013 - Elsevier
Flavohemoglobins (FHbs) are members of the globin superfamily, widely distributed among
prokaryotes and eukaryotes that have been shown to carry out nitric oxide dioxygenase …

Antimicrobial agents act differently on Staphyloccocus aureus and Ralstonia eutropha flavohemoglobins

A Ezzine, M Moussaoui, E El Hammi… - Applied biochemistry …, 2014 - Springer
Flavohemoglobins (FlavoHb) play a key role in bacterial resistance to nitrosative stress and
NO signaling modulation. In this study, we cloned, expressed, and characterized the flavoHb …

Structure of Ralstonia eutropha Flavohemoglobin in Complex with Three Antibiotic Azole Compounds

E El Hammi, E Warkentin, U Demmer, F Limam… - Biochemistry, 2011 - ACS Publications
Flavohemoglobins (flavoHbs) are enzymes that operate primarily as nitric oxide
dioxygenases and shuttle thereby electrons among NAD (P) H, FAD, heme, and a ligated …

Resonance Raman studies on the flavohemoglobin of the protist Giardia intestinalis: evidence of a type I/II-peroxidase-like heme environment and roles of the active …

B Lukaszewicz, E McColl, J Yee, S Rafferty… - JBIC Journal of …, 2017 - Springer
Flavohemoglobins are microbial enzymes that counter nitrosative stress, but the details of
their underlying enzymatic activities and structure–function relationships are not completely …

Active site analysis of yeast flavohemoglobin based on its structure with a small ligand or econazole

E El Hammi, E Warkentin, U Demmer… - The FEBS …, 2012 - Wiley Online Library
Flavohemoglobins (flavoHbs) serve various microorganisms as the major protective
enzymes against NO˙‐mediated toxicity. FlavoHbs dominantly function as an NO˙ …

New insights into the mechanism of electron transfer within flavohemoglobins: tunnelling pathways, packing density, thermodynamic and kinetic analyses

E El Hammi, C Houée-Lévin, J Řezáč, B Lévy… - Physical Chemistry …, 2012 - pubs.rsc.org
Flavohemoglobins (FlavoHb) are metalloenzymes catalyzing the reaction of nitric oxide
dioxygenation. The iron cation of the heme group needs to be preliminarily reduced to the …

Type II flavohemoglobin of Mycobacterium smegmatis oxidizes d-lactate and mediate electron transfer

N Thakur, A Kumar, KL Dikshit - International journal of biological …, 2018 - Elsevier
Two distantly related flavohemoglobins (FHbs), MsFHbI and Ms FHbII, having crucial
differences in their heme and reductase domains, co-exist in Mycobacterium smegmatis …

An unconventional hexacoordinated flavohemoglobin from Mycobacterium tuberculosis

S Gupta, S Pawaria, C Lu, MD Hade, C Singh… - Journal of Biological …, 2012 - ASBMB
Being an obligate aerobe, Mycobacterium tuberculosis faces a number of energetic
challenges when it encounters hypoxia and environmental stress during intracellular …

Flavohemoglobin: structure and reactivity

A Bonamore, A Boffi - IUBMB life, 2008 - Wiley Online Library
Flavohemoglobins (flavoHbs) are made of a globin domain fused with a ferredoxin
reductaselike FAD‐and NAD‐binding modules. These proteins are widely represented …