Regional differences in the effects of withdrawal from repeated cocaine upon Homer and glutamate receptor expression: a two-species comparison
AW Ary, KK Szumlinski - Brain research, 2007 - Elsevier
The constitutively expressed (CC) Homer protein Homer2a/b actively regulates behavioral
and neurochemical sensitivity to cocaine in both rats and mice. The present study employed …
and neurochemical sensitivity to cocaine in both rats and mice. The present study employed …
[HTML][HTML] Homer proteins regulate sensitivity to cocaine
KK Szumlinski, MH Dehoff, SH Kang, KA Frys… - Neuron, 2004 - cell.com
Drug addiction involves complex interactions between pharmacology and learning in
genetically susceptible individuals. Members of the Homer gene family are regulated by …
genetically susceptible individuals. Members of the Homer gene family are regulated by …
Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats
Addiction to cocaine results from changes in brain function arising from a combination of
pharmacology, environmental circumstances, as well as genetic vulnerability. One change is …
pharmacology, environmental circumstances, as well as genetic vulnerability. One change is …
Homer1 proteins and AMPA receptors modulate cocaine‐induced behavioural plasticity
MB Ghasemzadeh, LK Permenter… - European Journal of …, 2003 - Wiley Online Library
Homer proteins form functional assemblies in the excitatory postsynaptic density, and
withdrawal from repeated cocaine administration reduces the expression of Homer1b/c in …
withdrawal from repeated cocaine administration reduces the expression of Homer1b/c in …
Homer isoforms differentially regulate cocaine-induced neuroplasticity
KK Szumlinski, KE Abernathy, EB Oleson… - …, 2006 - nature.com
Homer proteins modulate neuroplasticity in excitatory synapses and are dynamically
regulated by cocaine. Whereas acute cocaine elevates immediate-early gene (short) …
regulated by cocaine. Whereas acute cocaine elevates immediate-early gene (short) …
Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: differential regulation by dopamine and glutamate signaling
MB Ghasemzadeh, LK Windham, RW Lake… - Synapse, 2009 - Wiley Online Library
Homer proteins are intracellular scaffolding proteins that, among glutamate receptors,
selectively bind to group1 metabotropic glutamate receptors and regulate their trafficking …
selectively bind to group1 metabotropic glutamate receptors and regulate their trafficking …
Behavioral and neurochemical phenotyping of mice incapable of Homer1a induction
MC Datko, JH Hu, M Williams, CM Reyes… - Frontiers in behavioral …, 2017 - frontiersin.org
Immediate early and constitutively expressed products of the Homer1 gene regulate the
functional assembly of post-synaptic density proteins at glutamatergic synapses to influence …
functional assembly of post-synaptic density proteins at glutamatergic synapses to influence …
In vivo regulation of Homer1a expression in the striatum by cocaine
GC Zhang, LM Mao, XY Liu, NK Parelkar, A Arora… - Molecular …, 2007 - ASPET
The glutamate receptor adaptor protein Homer is concentrated in the postsynaptic density of
excitatory synapses and is critical for normal operation of synaptic transmission. In this study …
excitatory synapses and is critical for normal operation of synaptic transmission. In this study …
Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference
AW Ary, KD Lominac, MG Wroten… - Journal of …, 2013 - Soc Neuroscience
Homer postsynaptic scaffolding proteins regulate forebrain glutamate transmission and thus,
are likely molecular candidates mediating hypofrontality in addiction. Protracted withdrawal …
are likely molecular candidates mediating hypofrontality in addiction. Protracted withdrawal …
Cocaine induces the expression of homer 1b/c, homer 3a/b, and hsp 27 proteins in rat cerebellum
JB Dietrich, MP Arpin‐Bott, D Kao, S Dirrig‐Grosch… - Synapse, 2007 - Wiley Online Library
The long homer proteins 1b/c, 2a/b, and 3a/b play an important role in postsynaptic neurons
by clustering glutamate receptors and by coupling the receptors with various intracellular …
by clustering glutamate receptors and by coupling the receptors with various intracellular …