The constitutively expressed (CC) Homer protein Homer2a/b actively regulates behavioral
and neurochemical sensitivity to cocaine in both rats and mice. The present study employed …

Drug addiction involves complex interactions between pharmacology and learning in
genetically susceptible individuals. Members of the Homer gene family are regulated by …

Addiction to cocaine results from changes in brain function arising from a combination of
pharmacology, environmental circumstances, as well as genetic vulnerability. One change is …

Homer proteins form functional assemblies in the excitatory postsynaptic density, and
withdrawal from repeated cocaine administration reduces the expression of Homer1b/c in …

Homer proteins modulate neuroplasticity in excitatory synapses and are dynamically
regulated by cocaine. Whereas acute cocaine elevates immediate-early gene (short) …

Homer proteins are intracellular scaffolding proteins that, among glutamate receptors,
selectively bind to group1 metabotropic glutamate receptors and regulate their trafficking …

Immediate early and constitutively expressed products of the Homer1 gene regulate the
functional assembly of post-synaptic density proteins at glutamatergic synapses to influence …

The glutamate receptor adaptor protein Homer is concentrated in the postsynaptic density of
excitatory synapses and is critical for normal operation of synaptic transmission. In this study …

Homer postsynaptic scaffolding proteins regulate forebrain glutamate transmission and thus,
are likely molecular candidates mediating hypofrontality in addiction. Protracted withdrawal …

The long homer proteins 1b/c, 2a/b, and 3a/b play an important role in postsynaptic neurons
by clustering glutamate receptors and by coupling the receptors with various intracellular …