Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

It is now nearly 5 years since the last of the currently recognised 5-HT receptors was
identified in terms of its cDNA sequence. Over this period, much effort has been directed …

Serotonin (5-hydroxytryptamine, 5-HT) is probably unique among the monoamines in that its
effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors …

After more than two decades of virtual stagnation, progress has recently been made in
understanding the pharmacology and function of 5-hydroxytryptamine (5-HT) receptor …

Activation of the 5-HT 4 receptor mediates widespread effects in central and peripheral
nervous systems. Recent developments, such as the identification of novel, selective …

In recent years, cloning has revealed the existence of no less than 14 mammalian 5-HT
receptors, as well as evidence that isoforms of the 5-HT 4 and 5-HT 7 receptors are …

The 5-ht5A receptor is enigmatic among 5-HT receptors since, although the human receptor
was cloned in 1994, until recently, very little has been learnt about the function of the …

The current classification for 5-HT 2 receptors accommodates three subtypes. In addition to
the originally defined 5-HT 2 receptor, sanctuary is now provided for the structurally related 5 …

Fourteen different receptor subtypes might be regarded as a diversity that is sufficient to
accommodate the wide-ranging physiological roles of 5-hydroxytryptamine (5-HT). However …

A comprehensive, state-of-the-art review of our current understanding of the molecular and
structural biology of 5-HT receptors and their potential use for drug discovery. The authors …