Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis
and is a major challenge to current treatments. Cancer cells commonly evade apoptosis …

BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members
sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as …

The importance of Bax for induction of tumor apoptosis through death receptors remains
unclear. Here we show that Bax can be essential for death receptor–mediated apoptosis in …

The BCL-2 family protein BAX is a central mediator of apoptosis. Overexpression of anti-
apoptotic BCL-2 proteins contributes to tumor development and resistance to therapy by …

Malignant cells routinely violate cellular checkpoints that should initiate cell death in normal
cells by triggering pro‐apoptotic members of the BCL‐2 family of proteins. To escape such …

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Antimitotic agents such as microtubule inhibitors (paclitaxel) are widely used in cancer
therapy while new agents blocking mitosis onset are currently in development. All these …

Impaired apoptosis is both critical in cancer development and a major barrier to effective
treatment. In response to diverse intracellular damage signals, including those evoked by …

Impairment of apoptosis, the physiologic cell death process, is central to cancer
development and renders tumors refractory to cytotoxic therapy. Bcl-2, the oncoprotein …

Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to
trigger apoptosis, whereas anti-apoptotic BCL-2 members preserve mitochondrial integrity …