Breast cancer (BC) is a leading cause of cancer deaths in Libyan women. BRCA1 variants
differ globally due to the diversity of genetic makeup and populations history. Their …

We previously reported BRCA1 mutations and sequence variants in Sri Lankan breast
cancer patients. Mutations and sequence variants of the BRCA2 gene were studied in 149 …

Abstract Background Breast Cancer is the most commonly diagnosed cancer among Sri
Lankan women. Germline mutations in the susceptibility genes BRCA1 and BRCA2 in …

Purpose: Germline mutations in either BRCA1 or BRCA2 genes are responsible for the
majority of hereditary breast and ovarian cancers. At present, over thousand distinct BRCA1 …

BRCA1 is known as a familial early onset breast cancer gene located in the long arm of
chromosome 17. Alterations in this gene have been reported in different populations, some …

Introduction The majority of hereditary breast and ovarian cancers are associated with
mutations in two genes, breast cancer type 1 and 2 susceptibility genes (BRCA1 and …

Women with breast carcinoma diagnosed before 40 years of age with a strong familial risk
have a greater prevalence of germline BRCA1 or BRCA2 variants than late onset breast …

Recent evidence from our laboratory as well as others suggests that specific variants in
BRCA1 and BRCA2 are associated with increased risk of breast cancer in women of African …

Background A large number of distinct mutations in the BRCA1 and BRCA2 genes have
been reported worldwide, but little is known regarding the role of these inherited …

Background Breast cancer is the most common malignancy in women worldwide. About 5%–
10% are due to hereditary predisposition. The contribution of BRCA1/2 mutations to familial …