Platelet lysate: a promising candidate in regenerative medicine

V Meftahpour, S Malekghasemi… - Regenerative …, 2021 - Taylor & Francis
Human platelet lysate has attracted much interest from many researchers as it is growth-
factor rich for cell expansion, which is employed as a new therapeutic strategy. Not only are …

Novel therapeutic approaches in utilizing platelet lysate in regenerative medicine: Are we ready for clinical use?

M Zamani, Y Yaghoubi… - Journal of cellular …, 2019 - Wiley Online Library
Hemoderivative materials are used to treat different diseases. These derivatives include
platelet‐rich plasma, serum, platelet gel, and platelet lysate (PL). Among them, PL contains …

Human platelet lysate–A potent (and overlooked) orthobiologic

L da Fonseca, GS Santos, SC Huber, TM Setti… - Journal of clinical …, 2021 - Elsevier
The knowledge of the essential role of platelets in tissue healing is gradually increasing and
as regenerative medicine prompts new solutions, platelet-derived bioproducts have been …

Effect of platelet lysate on human cells involved in different phases of wound healing

M Chiara Barsotti, P Losi, E Briganti, E Sanguinetti… - PloS one, 2013 - journals.plos.org
Background Platelets are rich in mediators able to positively affect cell activity in wound
healing. Aim of this study was to characterize the effect of different concentrations of human …

Platelet lysates and their role in cell therapy

S Radtke, B Giebel, W Wagner, PA Horn - ISBT Science Series, 2014 - Wiley Online Library
There is an emerging field of application for human platelet concentrates as they are rich in
growth factors for in vitro culture of various cell types. To this end, the platelets are lysed to …

Human platelet lysate: replacing fetal bovine serum as a gold standard for human cell propagation?

T Burnouf, D Strunk, MBC Koh, K Schallmoser - Biomaterials, 2016 - Elsevier
The essential physiological role of platelets in wound healing and tissue repair builds the
rationale for the use of human platelet derivatives in regenerative medicine. Abundant …

Regenerative effect of expired platelet concentrates in human therapy: An update

T Burnouf, HA Goubran - Transfusion and Apheresis Science, 2022 - Elsevier
There is concrete evidence that outdated allogeneic platelet concentrates not used for
transfusion are valuable sources of functional trophic factors, including growth factors …

Platelet derivatives in regenerative medicine: an update

MR De Pascale, L Sommese, A Casamassimi… - Transfusion medicine …, 2015 - Elsevier
Prior preclinical and clinical studies support the use of platelet-derived products for the
treatment of soft and hard tissue lesions. These regenerative effects are controlled by …

Novel applications of platelet concentrates in tissue regeneration

ZY Ding, Y Tan, Q Peng, J Zuo… - Experimental and …, 2021 - spandidos-publications.com
Numerous studies have explored the suitability of biocompatible materials in regenerative
medicine. Platelet concentrates are derived from centrifuged blood and are named …

Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & …

K Bieback, B Fernandez-Munoz, S Pati, R Schäfer - Cytotherapy, 2019 - Elsevier
Fetal bovine serum (FBS) is used as a growth supplement in a wide range of cell culture
applications for cell-based research and therapy. However, as a xenogenic product, FBS …