Clinical administration of paclitaxel is hindered due to its poor solubility, which necessitates
the formulation of novel drug delivery systems to deliver such extreme hydrophobic drug. To …

Purpose The aim of this work was to prepare paclitaxel-loaded PLGA nanoparticles and
determine cytotoxicity of released paclitaxel for two hypoxic human tumor cell lines: breast …

Taxanes, including paclitaxel, are anti-cancer drugs approved for the treatment of prostate
cancer but which have limited clinical application due to their hydrophobicity, their low …

This investigation described the development of novel PLGA: poloxamer blend
nanoparticles for intravenous administration of paclitaxel in order to limit the cremophor …

Paclitaxel is one of the best antineoplastic drugs found from nature in the past decades,
which has been found effective against a wide spectrum of cancers including ovarian …

The aim of this study is to formulate polymeric paclitaxel nanoparticles with various
stabilizers to improve solubility, enhance stability, maximize therapeutic efficacy and …

Purpose: The size of polymeric nanoparticles is considered as an effective factor in cancer
therapy due to enterance into tumor tissue via the EPR effect. The purpose of this work was …

The main objective of this study was to develop a polymeric drug delivery system for
paclitaxel, intended to be intravenously administered, capable of improving the therapeutic …

This study aimed at development of poly (lactic-co-glycolic acid)(PLGA) nanoparticles
embedded with paclitaxel and coated with hyaluronic acid (HA-PTX-PLGA) to actively target …

Abstract Objective: Paclitaxel (PTX)-loaded polymer (Poly (lactic-co-glycolic acid), PLGA)-
based nanoformulation was developed with the objective of formulating cremophor EL-free …