Highlights•Computational models are a useful tool to understand microbial metabolism.•
Challenges are complex media and interactions between metabolically diverse …

Genome-scale metabolic network reconstruction offers a means to leverage the value of the
exponentially growing genomics data and integrate it with other biological knowledge in a …

The biotechnology industry continuously explores new ways to improve the performance of
microbial strains in fermentation processes. Recent focus has been on new genome-wide …

Genome-scale metabolic models have proven to be valuable for predicting organism
phenotypes from genotypes. Yet efforts to develop new models are failing to keep pace with …

Lactic acid bacteria (LAB) have a long tradition of use in the food industry, and the number
and diversity of their applications has increased considerably over the years. Traditionally …

Genome-scale metabolic models are instrumental in uncovering operating principles of
cellular metabolism, for model-guided re-engineering, and unraveling cross-feeding in …

This review describes recent scientific and technological drivers of food fermentation
research. In addition, a number of practical implications of the results of this development …

Background The gut microbiota plays an important role in human health and disease by
acting as a metabolic organ. Metagenomic sequencing has shown how dysbiosis in the gut …

Construction and analysis of genome-scale metabolic models (GEMs) is a well-established
systems biology approach that can be used to predict metabolic and growth phenotypes …

The human gut hosts a complex community of microorganisms that directly influences
gastrointestinal physiology, playing a central role in human health. Because of its …