The pathogenic fungus C ryptococcus neoformans must overcome multiple stressors to
cause disease in its human host. In this study, we report that C. neoformans rapidly and …

Adaptation to host temperature is a prerequisite for any pathogen capable of causing deep
infection in humans. Our previous studies demonstrated that a Cryptococcus neoformans …

Cryptococcus neoformans is an environmental fungus that can cause severe disease in
humans. C. neoformans encounters a multitude of stresses within the human host to which it …

Little is known about how fungi adapt to chilling. In eubacteria, cold shock proteins (CSPs)
facilitate translation by destabilizing RNA secondary structure. Animals and plants have …

A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …

Summary The Crp/Fnr family of transcriptional regulators play central roles in transcriptional
control of diverse physiological responses, and are activated by a surprising diversity of …

Fungi are ubiquitous in the environment and humans constantly encounter them in the soil,
air, water, and food. The vast majority of these interactions are inconsequential. However, in …

The pathogenic fungus Cryptococcus neoformans must adapt to glucose‐limited conditions
in the lung and glucose replete conditions upon dissemination to the brain. We report that …

In response to the host environment, the human pathogen Cryptococcus neoformans must
rapidly reprogram its translatome from one which promotes growth to one which is …

Fungal infections are often difficult to treat due to the inherent similarities between fungal
and animal cells and the resulting host toxicity from many antifungal compounds …