Complement forms an important arm of innate immunity against invasive meningococcal
infections. Binding of the alternative complement pathway inhibitor factor H (fH) to fH-binding …

Neisseria meningitidis is a commensal of the human nasopharynx but is also a major cause
of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds …

Neisseria meningitidis is a Gram-negative microorganism that exists exclusively in humans
and can cause devastating invasive disease. Although capsular polysaccharide-based …

Among 25 serogroup B Neisseria meningitidis clinical isolates, we identified four (16%) with
high factor H binding protein (FHbp) expression that were resistant to complement-mediated …

Neisseria meningitidis binds factor H (fH), a key regulator of the alternative complement
pathway. A∼ 29 kD fH-binding protein expressed in the meningococcal outer membrane …

Neisseria meningitidis is a leading cause of sepsis and meningitis. The bacterium recruits
factor H (fH), a negative regulator of the complement system, to its surface via fH binding …

Neisseria meningitidis remains a leading cause of bacterial sepsis and meningitis.
Complement is a key component of natural immunity against this important human …

Background Antibodies to factor H (fH)–binding protein (fHBP), a meningococcal vaccine
antigen, activate classical complement pathway serum bactericidal activity (SBA) and block …

Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. The first broad-
spectrum multicomponent vaccine against serogroup B meningococcus (MenB), 4CMenB …

Neisseria meningitis remains a leading cause of sepsis and meningitis, and vaccines are
required to prevent infections by this important human pathogen. Factor H binding protein …