Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow
and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel …

This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Vascular endothelial cells (ECs) play significant roles in regulating circulatory functions.
Mechanical stimuli, including the stretch and shear stress resulting from circulatory pressure …

Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

Fluid shear stress is one of the most important mechanical forces acting upon vascular
endothelium, because of its location at the interface between the bloodstream and vascular …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

The endothelial cells (ECs) that line the inner layer of blood vessels are responsible for
maintaining vascular homeostasis under physiological conditions. In the presence of …

Vascular endothelial cells (ECs) play a central role in the control of blood vessel function
and circulatory system homeostasis. It is well known that that EC functions are regulated by …

Understanding how vascular wall endothelial cells (ECs), smooth muscle cells (SMCs), and
fibroblasts (FBs) sense and transduce the stimuli of hemodynamic forces (shear stress …

Vascular endothelial cells (ECs) and smooth muscle cells (VSMCs) are constantly exposed
to hemodynamic forces in vivo, including flow shear stress and cyclic stretch caused by the …