Lipid accumulation, inflammation, and oxidative stress are the most important causes of
muscle insulin resistance. The aim of this study was to investigate the single and combined …

Background Inflammation at the low-grade level has been found to contribute to obesity-
induced insulin resistance in the skeletal muscle (SM). This study investigated the anti …

Aim A growing interest to understand the signaling pathways mediating obesity‐induced
muscle atrophy is given. Metformin (Met) was reported to possess positive effects on …

Although the beneficial effects of metformin (MET) and genistein in ameliorating
inflammation have been elucidated, their combined impacts on skeletal muscle inflammation …

Metformin can act in muscle, inhibiting the complex I of the electron transport chain and
decreasing mitochondrial reactive oxygen species. Our hypothesis is that the inhibition of …

Metformin (METF), historical antihyperglycemic drug, is a likely candidate for lifespan
extension, treatment and prevention of sedentariness damages, insulin resistance, and …

Nutrient excess caused by excessive fructose intake can lead to insulin resistance and
dyslipidemia, which further causes the development of metabolic syndrome. Metformin is a …

Background: Obesity is a major risk factor for metabolic syndrome, including insulin
resistance (IR), type 2 dia-betes mellitus (T2DM), and cardiovascular disease; ectopic fat …

Background The purpose of this study was to determine whether a mixture of the
polyphenol, resveratrol, and the leucine metabolite, hydroxymethylbutyrate (HMB), acts …

Morin is a natural bioflavonoid that exhibits antioxidant and anti-inflammatory properties.
The present study was designed to evaluate the effect of morin on insulin resistance …