IL-6 revisited: from rheumatoid arthritis to CAR T cell therapy and COVID-19

T Kishimoto, S Kang - Annual review of Immunology, 2022 - annualreviews.org
The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …

Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach

M Aliyu, FT Zohora, AU Anka, K Ali, S Maleknia… - International …, 2022 - Elsevier
Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both
pro-inflammatory and anti-inflammatory activity, depending on the immune response …

[HTML][HTML] Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms

S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …

Interleukin 6: from bench to bedside

N Nishimoto, T Kishimoto - Nature clinical practice Rheumatology, 2006 - nature.com
Abstract Interleukin (IL)-6 is a pleiotropic cytokine that has important roles in the regulation of
the immune response, inflammation, and hematopoiesis. Disruption of IL-6 regulation might …

Interleukin (IL-6) immunotherapy

T Tanaka, M Narazaki… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When
homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and …

IL-6 in inflammation, immunity, and disease

T Tanaka, M Narazaki… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue
injuries, contributes to host defense through the stimulation of acute phase responses …

[HTML][HTML] Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases

T Tanaka, T Kishimoto - International journal of biological sciences, 2012 - ncbi.nlm.nih.gov
Abstract Interleukin (IL)-6, a cytokine featuring redundancy and pleiotropic activity,
contributes to host defense against acute environmental stress, while dysregulated …

A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy

T Tanaka, M Narazaki, A Ogata, T Kishimoto - Seminars in immunology, 2014 - Elsevier
Abstract Interleukin-6 (IL-6) is a cytokine with redundant and pleiotropic activities, and its
synthesis is tightly regulated by transcriptional and posttranscriptional mechanisms. When …

[HTML][HTML] Interleukin 6: at the interface of human health and disease

E Grebenciucova, S VanHaerents - Frontiers in immunology, 2023 - frontiersin.org
Interleukin 6 (IL-6) is a pleiotropic cytokine executing a diverse number of functions, ranging
from its effects on acute phase reactant pathways, B and T lymphocytes, blood brain barrier …

Interleukin 6 and rheumatoid arthritis

Y Yoshida, T Tanaka - BioMed research international, 2014 - Wiley Online Library
Interleukin‐6 (IL‐6) is a representative cytokine featuring pleiotropic activity and
redundancy. A transient synthesis of IL‐6 contributes to host defense against infectious …