IL-6 revisited: from rheumatoid arthritis to CAR T cell therapy and COVID-19
T Kishimoto, S Kang - Annual review of Immunology, 2022 - annualreviews.org
The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …
Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach
Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both
pro-inflammatory and anti-inflammatory activity, depending on the immune response …
pro-inflammatory and anti-inflammatory activity, depending on the immune response …
[HTML][HTML] Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
Interleukin 6: from bench to bedside
N Nishimoto, T Kishimoto - Nature clinical practice Rheumatology, 2006 - nature.com
Abstract Interleukin (IL)-6 is a pleiotropic cytokine that has important roles in the regulation of
the immune response, inflammation, and hematopoiesis. Disruption of IL-6 regulation might …
the immune response, inflammation, and hematopoiesis. Disruption of IL-6 regulation might …
Interleukin (IL-6) immunotherapy
T Tanaka, M Narazaki… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When
homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and …
homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and …
IL-6 in inflammation, immunity, and disease
T Tanaka, M Narazaki… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue
injuries, contributes to host defense through the stimulation of acute phase responses …
injuries, contributes to host defense through the stimulation of acute phase responses …
[HTML][HTML] Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases
T Tanaka, T Kishimoto - International journal of biological sciences, 2012 - ncbi.nlm.nih.gov
Abstract Interleukin (IL)-6, a cytokine featuring redundancy and pleiotropic activity,
contributes to host defense against acute environmental stress, while dysregulated …
contributes to host defense against acute environmental stress, while dysregulated …
A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy
T Tanaka, M Narazaki, A Ogata, T Kishimoto - Seminars in immunology, 2014 - Elsevier
Abstract Interleukin-6 (IL-6) is a cytokine with redundant and pleiotropic activities, and its
synthesis is tightly regulated by transcriptional and posttranscriptional mechanisms. When …
synthesis is tightly regulated by transcriptional and posttranscriptional mechanisms. When …
[HTML][HTML] Interleukin 6: at the interface of human health and disease
E Grebenciucova, S VanHaerents - Frontiers in immunology, 2023 - frontiersin.org
Interleukin 6 (IL-6) is a pleiotropic cytokine executing a diverse number of functions, ranging
from its effects on acute phase reactant pathways, B and T lymphocytes, blood brain barrier …
from its effects on acute phase reactant pathways, B and T lymphocytes, blood brain barrier …
Interleukin 6 and rheumatoid arthritis
Y Yoshida, T Tanaka - BioMed research international, 2014 - Wiley Online Library
Interleukin‐6 (IL‐6) is a representative cytokine featuring pleiotropic activity and
redundancy. A transient synthesis of IL‐6 contributes to host defense against infectious …
redundancy. A transient synthesis of IL‐6 contributes to host defense against infectious …