The dosing of tacrolimus, which forms the backbone of immunosuppressive therapy after
kidney transplantation, is complex. This is due to its variable pharmacokinetics (both …

Measurement of pre‐dose tacrolimus concentrations, also referred to as trough
concentrations or C0 (in this paper the term C0 will be used), is the most frequently used …

Aims To evaluate the relationship between tacrolimus whole blood concentrations and side‐
effects and rejections in 14 renal transplant recipients. Methods Tacrolimus was measured …

Once-daily tacrolimus is a new oral formulation of the established immunosuppressive agent
tacrolimus (Prograf, Astellas Pharma US, Inc., Deerfield, IL), which is administered twice …

ABSTRACT Introduction: Tacrolimus (Tac) is the cornerstone of immunosuppressive therapy
after solid organ transplantation and will probably remain so. Excluding belatacept, no new …

British Journal of Clinical Pharmacology. The authors describe the target concentration
intervention (TCI) concept and oppose it to the principle of therapeutic drug monitoring …

Initial clinical trials of FK did not incorporate available FK levels, and difficulties were quickly
experienced particularly with neurotoxicity and nephrotoxicity. The introduction of routine …

This study compared an enzyme-linked immunosorbent assay (ELISA) to a liquid
chromatography–tandem mass spectrometry (LC/MS/MS) technique for measurement of …

Introduction: Transplant nurse coordinators have assisted in accurately adjusting tacrolimus
doses under a collaborative practice agreement for kidney transplant recipients in the early …

Ten years ago, a consensus report on the optimization of tacrolimus was published in this
journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International …