Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian and colorectal cancer

A Meunier, JA Hernández-Castro, N Chahley… - BioRxiv, 2019 - biorxiv.org
Circulating tumor cells (CTCs) are rare (few cells per milliliter of blood) and mostly isolated
as single cell CTCs (scCTCs). CTC clusters (cCTCs), even rarer, are of growing interest …

Clusters of circulating tumor cells were selectively isolated in the blood of 12/12 epithelial ovarian cancer patients using facile gravity-flow-based filtration method …

A Meunier, S Kheireddine, JA Hernández-Castro… - Cancer Research, 2018 - AACR
Background The presence of circulating tumor cells (CTCs) in blood is correlated with
disease progression in many cancers. Their prognosis value in ovarian cancer is still under …

[HTML][HTML] High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells

M Boya, T Ozkaya-Ahmadov, BE Swain, CH Chu… - Nature …, 2022 - nature.com
Extremely rare circulating tumor cell (CTC) clusters are both increasingly appreciated as
highly metastatic precursors and virtually unexplored. Technologies are primarily designed …

Micromanipulation of circulating tumor cells for downstream molecular analysis and metastatic potential assessment

C Donato, BM Szczerba, MC Scheidmann… - JoVE (Journal of …, 2019 - jove.com
Blood-borne metastasis accounts for most cancer-related deaths and involves circulating
tumor cells (CTCs) that are successful in establishing new tumors at distant sites. CTCs are …

[HTML][HTML] Isolation of circulating tumor cells

JF Edd, A Mishra, KC Smith, R Kapur, S Maheswaran… - Iscience, 2022 - cell.com
Circulating tumor cells (CTCs) enter the vasculature from solid tumors and disseminate
widely to initiate metastases. Mining the metastatic-enriched molecular signatures of CTCs …

[HTML][HTML] Hypoxia triggers the intravasation of clustered circulating tumor cells

C Donato, L Kunz, F Castro-Giner, A Paasinen-Sohns… - Cell reports, 2020 - cell.com
Circulating tumor cells (CTCs) are shed from solid cancers in the form of single or clustered
cells, and the latter display an extraordinary ability to initiate metastasis. Yet, the biological …

[HTML][HTML] Circulating tumor cell clusters: What we know and what we expect

Y Hong, F Fang, Q Zhang - … journal of oncology, 2016 - spandidos-publications.com
The major cause of cancer-associated mortality is tumor metastasis, a disease that is far
from understood. Many studies have observed circulating tumor cells (CTCs) in patients' …

[HTML][HTML] Better together: circulating tumor cell clustering in metastatic cancer

E Schuster, R Taftaf, C Reduzzi, MK Albert… - Trends in cancer, 2021 - cell.com
Circulating tumor cells (CTCs) are vital components of liquid biopsies for diagnosis of
residual cancer, monitoring of therapy response, and prognosis of recurrence. Scientific …

Single-cell analysis of circulating tumour cells: enabling technologies and clinical applications

P Radfar, HA Es, R Salomon, A Kulasinghe… - Trends in …, 2022 - cell.com
Multimodal analysis of circulating tumour cells (CTCs) has the potential to provide
remarkable insight for cancer development and metastasis. CTCs and CTC clusters …

Circulating tumor cells: strategies for capture, analyses, and propagation

A Agarwal, M Balic, D El-Ashry, RJ Cote - The Cancer Journal, 2018 - journals.lww.com
Circulating tumor cells (CTCs) play a central role in tumor dissemination and metastases,
which are ultimately responsible for most cancer deaths. Technologies that allow for …