Culture-independent metagenomic studies have revolutionized our understanding of the gut
microbiota. However, the lack of full genomes from cultured species is still a limitation for in …

Understanding gut microbiome functions requires cultivated bacteria for experimental
validation and reference bacterial genome sequences to interpret metagenome datasets …

Reference genomes are essential for metagenomic analyses and functional characterization
of the human gut microbiota. We present the Culturable Genome Reference (CGR), a …

The genome sequences of many species of the human gut microbiome remain unknown,
largely owing to challenges in cultivating microorganisms under laboratory conditions. Here …

Metagenome-based resources have revealed the diversity and function of the human gut
microbiome, but further understanding is limited by insufficient genome quality and a lack of …

The gut is the richest ecosystem of microbes in the human body and has great influence on
our health. Despite many efforts, the set of microbes inhabiting this environment is not fully …

The composition of the human gut microbiota is linked to health and disease, but knowledge
of individual microbial species is needed to decipher their biological roles. Despite …

Comprehensive, high-quality reference genomes are required for functional characterization
and taxonomic assignment of the human gut microbiota. We present the Unified Human …

Background Obtaining high-quality (HQ) reference genomes from microbial communities is
crucial for understanding the phylogeny and function of uncultured microbes in complex …

Background Metagenome sampling bias for geographical location and lifestyle is partially
responsible for the incomplete catalog of reference genomes of gut microbial species. Thus …