Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

Investigation into the regulation of the erythropoietin gene by oxygen led to the discovery of
a process of direct oxygen sensing that transduces many cellular and systemic responses to …

The kidney is sensitive to changes in oxygen delivery. This sensitivity has the merit of
facilitating the kidneys in their adjustment of erythropoietin (EPO) production to changes in …

Adaptation to hypoxia is a topic of considerable clinical relevance, as it influences the
pathophysiology of anaemia, polycythaemia, tissue ischaemia and cancer. A growing …

Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …

This article outlines the need for a homeostatic response to alterations in cellular
oxygenation. It describes work on erythropoietin control that led to the discovery of the …

The number of red blood cells is normally tightly regulated by a classic homeostatic
mechanism based on oxygen sensing in the kidney. Decreased oxygen delivery resulting …

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the
hypoxic induction of red blood cell production. Efforts to understand the molecular basis of …

Tissue hypoxia occurs when local metabolism is disturbed by an imbalance between
oxygen supply and consumption. In patients with chronic kidney disease, chronic hypoxia in …

The hypoxia-inducible factor 1 (HIF-1) was initially identified as a transcription factor that
regulated erythropoietin gene expression in response to a decrease in oxygen availability in …