Ketanserin: a novel cardiovascular drug
J Symoens, M Janssens - Drug Development Research, 1986 - Wiley Online Library
Extensive clinical investigation has shown that ketanserin is an effective first‐line
antihypertensive agent with particular advantages in older patients. It has a favorable …
antihypertensive agent with particular advantages in older patients. It has a favorable …
Ketanserin: a new hypotensive drug?
A Amery, R Fagard, R Fiocchi, P Lijnen… - Journal of …, 1985 - journals.lww.com
The possible use of ketanserin for the chronic treatment of patients with essential
hypertension was discussed based on the data exposed at this symposium. Its hypotensive …
hypertension was discussed based on the data exposed at this symposium. Its hypotensive …
Ketanserin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in hypertension and peripheral vascular disease
RN Brogden, EM Sorkin - Drugs, 1990 - Springer
Ketanserin is a 5-HT 2 receptor antagonist without partial agonist properties which also
possesses weak α 1-adrenoceptor antagonistic activity, which may explain its …
possesses weak α 1-adrenoceptor antagonistic activity, which may explain its …
A comparative and long-term evaluation of ketanserin in the treatment of essential hypertension
T Hedner, B Persson, G Berglund - Journal of Cardiovascular …, 1985 - journals.lww.com
Ketanserin is a serotonin (S,) Mocker that reduces blood pressure (BP) in patients with
essential hypertension preferentially by a reduction of peripheral vascular resistance. Heart …
essential hypertension preferentially by a reduction of peripheral vascular resistance. Heart …
Ketanserin: a novel cardiovascular drug
J Symoens - Blood Coagulation & Fibrinolysis, 1990 - journals.lww.com
Ketanserin is the archetype of a new class of cardiovascular drugs, the 5HT 2 (S 2)
serotonergic receptor antagonists. In humans, ketanserin inhibits serotonin-induced …
serotonergic receptor antagonists. In humans, ketanserin inhibits serotonin-induced …
Ketanserin: a possible tool for studying the role of serotonin in hypertension
AJJ Woittiez, GJ Wonting, AJ Man't Veld… - Journal of …, 1985 - journals.lww.com
Ketanserin is a serotonin antagonist with high affinity for S2-serotonergic receptors, which
mediate the vasoconstrictor effects of serotonin. It does not block the vasodilator effects of …
mediate the vasoconstrictor effects of serotonin. It does not block the vasodilator effects of …
Antihypertensive efficacy of ketanserin alone or in combination with a β-blocker or a diuretic: the Swiss Ketanserin Study
C Beretta-Piccoli, R Amstein, O Bertel… - Journal of …, 1987 - journals.lww.com
In the Swiss Ketanserin Study the antihypertensive efficacy and tolerability of ketanserin
(given in 20 or 40 mg doses twice daily) was investigated, after a placebo run-in phase, as …
(given in 20 or 40 mg doses twice daily) was investigated, after a placebo run-in phase, as …
Clinical studies with ketanserin in hypertension
HJ Waal-Manning, SA Brown, GF Spears… - Journal of …, 1985 - journals.lww.com
To assess efficacy and side effects during chronic oral therapy, we studied the effect of
ketanserin (Kn) in 17 hypertensive patients for a period up to 1 year. Ketanserin controlled …
ketanserin (Kn) in 17 hypertensive patients for a period up to 1 year. Ketanserin controlled …
Effects of a new serotonin antagonist, ketanserin, in experimental and clinical hypertension
T Hedner, B Persson - American Journal of Hypertension, 1988 - academic.oup.com
Ketanserin is an agent whose main pharmacologic action is antagonism of serotonin (5-
hydroxytryptamine, 5HT) receptors of the 5HT2 subtype. It also has weak α1-adrenergic …
hydroxytryptamine, 5HT) receptors of the 5HT2 subtype. It also has weak α1-adrenergic …
Experience With Ketanserin, A Serotonin (S2) Antagonist, in Longterm Treatment of Essential Hypertension
T Hedner, B Persson, G Berglund - Clinical and Experimental …, 1984 - Taylor & Francis
Ketanserin is a quinazoline derivative which acts selectively on serotonin (S2) receptors.
The compound has been shown to possess antihypertensive properties. BP and HR were …
The compound has been shown to possess antihypertensive properties. BP and HR were …