The selection of drug-resistant pathogens in hospitalized patients with serious infections
such as pneumonia, urinary tract infections (UTI), skin and skin-structure infections, and …

Rising antibiotic resistance rates among bacterial pathogens have resulted in increased
morbidity and mortality from nosocomial infections. Widespread use of certain antibiotics …

The continued evolution of antimicrobial resistance in the hospital and more recently in the
community threatens to seriously compromise our ability to treat serious infections. The …

The emergence of bacterial resistance to antibacterial agents continues to be an important
clinical problem, although it is not shared equally by all bacterial species and classes of …

Accumulating evidence indicates that treating seriously ill infected patients with active
antibiotics early in the course of infection is critical to improving outcomes. The most …

Multiple surveillance studies have demonstrated that resistance among prevalent pathogens
is increasing at an alarming rate, leading to greater patient morbidity and mortality from …

The widespread emergence of antibiotic‐resistant gram‐negative organisms has
compromised the utility of current treatment options for severe infections caused by these …

About 5% of patients admitted to acute-care hospitals acquire nosocomial infections. A
variety of factors contribute: increasing age of patients; availability, for treatment of formerly …

The increasing prevalence of antibiotic resistance is a threat to human health, particularly
within vulnerable populations in the hospital and acute care settings. This leads to …

The antimicrobial resistance problem in hospitals continues to worsen. In particular,
extended-spectrum β-lactamase–producing Klebsiella pneumoniae (ESBL-KP) and …