Botcinic acid biosynthesis in Botrytis cinerea relies on a subtelomeric gene cluster surrounded by relics of transposons and is regulated by the Zn2Cys6 …

A Porquier, J Moraga, G Morgant, B Dalmais, A Simon… - Current genetics, 2019 - Springer
Botcinic acid is a phytotoxic polyketide involved in the virulence of the gray mold fungus
Botrytis cinerea. Here, we aimed to investigate the specific regulation of the cluster of Bcboa …

Screening of a Botrytis cinerea one-hybrid library reveals a Cys2His2 transcription factor involved in the regulation of secondary metabolism gene clusters

A Simon, B Dalmais, G Morgant, M Viaud - Fungal Genetics and Biology, 2013 - Elsevier
Botrytis cinerea, the grey mould fungus, secretes non-host-specific phytotoxins that kill the
cells of many plant species. Phytotoxic assays performed about ten years ago, have …

The botrydial biosynthetic gene cluster of Botrytis cinerea displays a bipartite genomic structure and is positively regulated by the putative Zn (II) 2Cys6 transcription …

A Porquier, G Morgant, J Moraga, B Dalmais… - Fungal genetics and …, 2016 - Elsevier
Botrydial (BOT) is a non-host specific phytotoxin produced by the polyphagous
phytopathogenic fungus Botrytis cinerea. The genomic region of the BOT biosynthetic gene …

The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial

B Dalmais, J Schumacher, J Moraga… - Molecular plant …, 2011 - Wiley Online Library
The grey mould fungus Botrytis cinerea produces two major phytotoxins, the sesquiterpene
botrydial, for which the biosynthesis gene cluster has been characterized previously, and the …

Sesquiterpene Synthase from the Botrydial Biosynthetic Gene Cluster of the Phytopathogen Botrytis cinerea

C Pinedo, CM Wang, JM Pradier, B Dalmais… - ACS chemical …, 2008 - ACS Publications
The fungus Botrytis cinerea is the causal agent of the economically important gray mold
disease that affects more than 200 ornamental and agriculturally important plant species. B …

Impairment of botrydial production in Botrytis cinerea allows the isolation of undescribed polyketides and reveals new insights into the botcinins biosynthetic pathway

J Moraga, IIB Reina, C Pinedo, R Hernández-Galán… - Phytochemistry, 2021 - Elsevier
Botrytis cinerea is a necrotrophic fungal pathogen that affects a total of 586 genera
representing approximately 1400 plant species. This pathogen produces two families of …

Functional Analysis of the Cytochrome P450 Monooxygenase Gene bcbot1 of Botrytis cinerea Indicates That Botrydial Is a Strain-Specific Virulence Factor

V Siewers, M Viaud, D Jimenez-Teja… - Molecular plant …, 2005 - Am Phytopath Society
The micrographic phytopathogen Botrytis cinerea causes gray mold diseases in a large
number of dicotyledonous crop plants and ornamentals. Colonization of host tissue is …

A shared biosynthetic pathway for botcinins and botrylactones revealed through gene deletions

M Massaroli, J Moraga, K Bastos Borges… - …, 2013 - Wiley Online Library
Isotopic labelling experiments and the study of mutants with disrupted genes encoding
botcinic acid have revealed a common link in the biosynthesis of the polyketide toxins …

Secondary Metabolism in Botrytis cinerea: Combining Genomic and Metabolomic Approaches

IG Collado, M Viaud - Botrytis–the fungus, the pathogen and its …, 2016 - Springer
Filamentous fungi produce a wide variety of bioactive secondary metabolites that play roles
in development and fitness. In the pre-genomic era of Botrytis cinerea research, already …

Repeated loss of an anciently horizontally transferred gene cluster in Botrytis

MA Campbell, M Staats, JAL van Kan, A Rokas… - Mycologia, 2013 - Taylor & Francis
At least five of the six genes of the bikaverin secondary metabolic gene cluster were shown
to have undergone horizontal transfer (HGT) from a Fusarium donor to the Botrytis lineage …