Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

Once tumor cells metastasize to the bone, the prognosis for prostate cancer patients is
generally very poor. The mechanisms involved in bone metastasis, however, remain elusive …

PURPOSE: The metastasis of prostate cancer to bone is the most significant cause of
morbidity and mortality in this disease. An estimated 28,900 men die annually secondary to …

Bone is the most common site for metastasis in human prostate cancer patients. Skeletal
metastases are a significant cause of morbidity and mortality and overall greatly affect the …

Skeletal metastasis in advanced prostate cancer (PCa) patients remains a significant cause
of morbidity and mortality. Research utilizing animal models during the past decade has …

Prostate cancer is a complex disease in which metastasis to the bone is the main cause of
death. Initial stages of metastasis are generally similar to those for most solid tumors; …

Prostate cancer (PCa) prognosis and clinical outcome is directly dependent on metastatic
occurrence. The bone microenvironment is a favorable metastatic niche. Different biological …

Abstract Learning Objectives After completing this course, the reader will be able to:
Recognize the biology underlying metastatic prostate cancer to bone. Identify the clinical …

Traditionally, prostate cancer treatment, as well as all cancer treatment, has been designed
to target the tumor cell directly via various hormonal and chemotherapeutic agents …

Metastasis is the leading cause of cancer-related death and drives patient morbidity as well
as healthcare costs. Bone is the primary site of metastasis for several cancers—breast and …