Structural chemistry and molecular-level interactome reveals histidine kinase EvgS to subvert both antimicrobial resistance and virulence in Shigella flexneri 2a str …

A Naha, S Ramaiah - 3 Biotech, 2022 - Springer
Multi-drug resistant (MDR) Shigella flexneri 2a, one of the leading bacterial agents of
diarrhoeal mortality, has posed challenges in treatment strategies. The present study was …

Genome‐Wide Investigation Reveals Potential Therapeutic Targets in Shigella spp.

MA Hossain, M Al Amin, MA Khan… - BioMed Research …, 2024 - Wiley Online Library
Shigella stands as a major contributor to bacterial dysentery worldwide scale, particularly in
developing countries with inadequate sanitation and hygiene. The emergence of multidrug …

Translational protein RpsE as an alternative target for novel nucleoside analogues to treat MDR Enterobacter cloacae ATCC 13047: network analysis and molecular …

R Debroy, S Ramaiah - World Journal of Microbiology and Biotechnology, 2023 - Springer
The pathogenic Enterobacter cloacae subsp. cloacae str. ATCC 13047 has contemporarily
emerged as a multi-drug resistant strain. To formulate an effective treatment option …

Finding Potential Therapeutic Targets against Shigella flexneri through Proteome Exploration

MU Hossain, MA Khan, A Hashem, MM Islam… - Frontiers in …, 2016 - frontiersin.org
Background: Shigella flexneri is a gram negative bacteria that causes the infectious disease
“shigellosis.” S. flexneri is responsible for developing diarrhea, fever, and stomach cramps in …

[HTML][HTML] Identification of therapeutic drug target of Shigella Flexneri serotype X through subtractive genomic approach and in-silico screening based on drug …

MH Ahmed, K Khan, S Tauseef, K Jalal… - Infection, Genetics and …, 2024 - Elsevier
Shigellosis, induced by Shigella flexneri, constitutes a significant health burden in
developing nations, particularly impacting socioeconomically disadvantaged communities …

[HTML][HTML] Shigella pathogenesis: molecular and computational insights

S Mukhopadhyay, S Ganguli… - AIMS Molecular …, 2020 - aimspress.com
Shigellosis, characterized by inflammation and ulceration of the large intestine, is caused by
infection with Shigella species. It is a major public health problem in developing countries …

Identification of potential drug targets and inhibitor of the pathogenic bacteria Shigella flexneri 2a through the subtractive genomic approach

AR Oany, M Mia, T Pervin, MN Hasan… - In Silico Pharmacology, 2018 - Springer
Shigella flexneri 2a is one of the most pathogenic bacteria among the Shigella spp., which is
responsible for dysentery and causes masses of deaths throughout the world per year. A …

[HTML][HTML] An in silico hierarchal approach for drug candidate mining and validation of natural product inhibitors against pyrimidine biosynthesis enzyme in the antibiotic …

Z Basharat, K Khan, K Jalal, D Ahmad, A Hayat… - Infection, Genetics and …, 2022 - Elsevier
Shigella flexneri is the main causative agent of the communicable diarrheal disease,
shigellosis. It is estimated that about 80–165 million cases and> 1 million deaths occur every …

In Silico Characterization of a Hypothetical Protein from Shigella dysenteriae ATCC 12039 Reveals a Pathogenesis-Related Protein of the Type-VI Secretion System

MF Rabbi, SA Akter, MJ Hasan… - … and biology insights, 2021 - journals.sagepub.com
Shigellosis caused by Shigella dysenteriae is a major public health concern worldwide,
particularly in developing countries. The bacterial genome is known, but there are many …

iTRAQ-Based Differential Proteomic Analysis Reveals the Pathways Associated with Tigecycline Resistance in Acinetobacter baumannii

N Yang, Y Liu, P He, R Ke, Y Zhao, Y Feng… - Cellular Physiology and …, 2018 - karger.com
Abstract Background/Aims: Acinetobacter baumannii is an aerobic and Gram-negative
bacterial pathogen with high morbidity and mortality. It remains a serious public health …