Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques

NM Htun, YC Chen, B Lim, T Schiller… - Nature …, 2017 - nature.com
Atherosclerosis is a major cause of mortality and morbidity, which is mainly driven by
complications such as myocardial infarction and stroke. These complications are caused by …

Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques

MA Calfon, C Vinegoni… - Journal of biomedical …, 2010 - spiedigitallibrary.org
New imaging methods are urgently needed to identify high-risk atherosclerotic lesions prior
to the onset of myocardial infarction, stroke, and ischemic limbs. Molecular imaging offers a …

Label-free visualization and quantification of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime

J Bec, D Vela, JE Phipps, M Agung, J Unger… - Cardiovascular …, 2021 - jacc.org
Objectives This study aimed to systematically investigate whether plaque autofluorescence
properties assessed with intravascular fluorescence lifetime imaging (FLIm) can provide …

Clinical characterization of coronary atherosclerosis with dual-modality OCT and near-infrared autofluorescence imaging

GJ Ughi, H Wang, E Gerbaud, JA Gardecki… - JACC: Cardiovascular …, 2016 - jacc.org
Objectives: The authors present the clinical imaging of human coronary arteries in vivo using
a multimodality optical coherence tomography (OCT) and near-infrared autofluorescence …

Near-infrared spectroscopic characterization of human advanced atherosclerotic plaques

J Wang, YJ Geng, B Guo, T Klima, BN Lal… - Journal of the American …, 2002 - jacc.org
Objectives: Living human carotid atherosclerotic plaques were examined in vitro by near-
infrared (NIR) spectroscopy to determine the spectral features of plaque vulnerability …

Intravascular molecular imaging: near-infrared fluorescence as a new frontier

H Khraishah, FA Jaffer - Frontiers in Cardiovascular Medicine, 2020 - frontiersin.org
Despite exciting advances in structural intravascular imaging [intravascular ultrasound
(IVUS) and optical coherence tomography (OCT)] that have enabled partial assessment of …

Multimodal characterization of compositional, structural and functional features of human atherosclerotic plaques

Y Sun, AJ Chaudhari, M Lam, H Xie… - Biomedical optics …, 2011 - opg.optica.org
Detection of atherosclerotic plaque vulnerability has critical clinical implications for avoiding
sudden death in patients with high risk of plaque rupture. We report on multimodality …

In vivo near infrared fluorescence (NIRF) intravascular molecular imaging of inflammatory plaque, a multimodal approach to imaging of atherosclerosis

MA Calfon, A Rosenthal, G Mallas, A Mauskapf… - JoVE (Journal of …, 2011 - jove.com
The vascular response to injury is a well-orchestrated inflammatory response triggered by
the accumulation of macrophages within the vessel wall leading to an accumulation of lipid …

Hyperspectral imaging of atherosclerotic plaques in vitro

ELP Larsen, LL Randeberg, E Olstad… - … of biomedical optics, 2011 - spiedigitallibrary.org
Vulnerable plaques constitute a risk for serious heart problems, and are difficult to identify
using existing methods. Hyperspectral imaging combines spectral-and spatial information …

Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques

Y Narita, K Shimizu, K Ikemoto, R Uchino… - Journal of Controlled …, 2019 - Elsevier
The development of atherosclerotic plaques is a critical step that can result in an arterial
embolism. Therefore, detection of these vulnerable plaques is of clinical significance for the …