The sources and consequences of nongenetic variability in metastatic progression are
largely unknown. To address these questions, we characterized a transcriptional regulatory …

Elucidating targets of physiological tumor metastasis suppressors can highlight key
signaling pathways leading to invasion and metastasis. To identify downstream targets of …

Tumour metastasis suppressors are inhibitors of metastasis but their mechanisms of action
are generally not understood. We previously showed that the suppressor Raf kinase …

Cancer is one of the deadliest diseases worldwide, accounting for about 8 million deaths a
year. For solid tumors, cancer patients die as a result of the metastatic spread of the tumor to …

Triple-negative breast cancer (TNBC) patients have the highest risk of recurrence and
metastasis. Because they cannot be treated with targeted therapies, and many do not …

Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a
metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a …

Accumulating evidence suggests that presence of macrophages in the tumor
microenvironment add to the invasive and tumor-promoting hallmarks of cancer cells by …

Diminished expression of the metastasis suppressor protein RKIP was previously reported
in a number of cancers. The underlying mechanism remains unknown. Here, we show that …

The metastatic cascade is a complicated process that involves many steps from gain of the
metastatic phenotype in the primary tumor cells through establishment of macroscopic tumor …

Prohibitin (PHB) is indispensable for Ras-induced Raf-1 activation, cell migration and
growth; however, the exact role of PHB in the molecular pathogenesis of cancer metastasis …