Background Plasmodium vivax malaria has a persistent liver stage that causes relapse of
the disease and continued P vivax transmission. Primaquine (PQ) is used to clear the liver …

Background Plasmodium vivax malaria is widespread, and the persistent liver stage causes
relapse of the disease which contributes to continued P. vivax transmission. Primaquine is …

Primaquine for preventing relapses in people with Plasmodium vivax malaria - Galappaththy,
GNL - 2007 | Cochrane Library Skip to Content Cookies Our site uses cookies to improve …

Background Malaria caused by Plasmodium vivax requires treatment of the blood‐stage
infection and treatment of the hypnozoites that develop in the liver. This is a challenge to …

Background Plasmodium vivax infections are an important contributor to the malaria burden
worldwide. The World Health Organization recommends a 14‐day course of primaquine …

Background Plasmodium vivax liver stages (hypnozoites) may cause relapses, prolonging
morbidity, and impeding malaria control and elimination. The World Health Organization …

Background Plasmodium vivax is a frequent cause of recurring malaria in endemic areas as
in its latent stage it resides in liver, and is responsible for relapse. Treatment with 8 …

Background Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been
associated with relapse prevention through the clearance of P. vivax parasitemia and …

Tafenoquine is an 8-aminoquinoline with activity against all human life cycle stages of
Plasmodium vivax, including dormant liver stages–so called hypnozoites. Its long half-life …

A single 300 mg dose of tafenoquine, in combination with chloroquine, is currently approved
in several countries for the radical cure (prevention of relapse) of Plasmodium vivax malaria …