New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis

Y Hou, J Zhao, W Martin, A Kallianpur, MK Chung… - BMC medicine, 2020 - Springer
Abstract Background Coronavirus Disease 2019 (COVID-19), caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has now been confirmed worldwide …

Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes

EA Lopera Maya, A Van der Graaf, P Lanting… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease 2019 (COVID-19) shows a wide variation in expression and severity of
symptoms, from very mild or no symptoms, to flu-like symptoms, and in more severe cases …

ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease

HO Singh, R Choudhari, V Nema, AA Khan - Microbial pathogenesis, 2021 - Elsevier
Background A carboxypeptidase protein called ACE2 is found in many organs. ACE2
protein can play a pivotal role to regulate the pathological changes of several diseases …

[HTML][HTML] Role of genetic variants and gene expression in the susceptibility and severity of COVID-19

S Choudhary, K Sreenivasulu, P Mitra… - Annals of laboratory …, 2021 - ncbi.nlm.nih.gov
Since its first report in December 2019, coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly emerged as a …

Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with COVID‐19 severity: A systematic review with meta‐analysis

W Saengsiwaritt, J Jittikoon… - Reviews in medical …, 2022 - Wiley Online Library
Abstract Novel coronavirus disease 2019 (COVID‐19) poses a global threat, due to its
fluctuating frequency and lethality. Published data revealed associations of COVID‐19 …

Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

JE Horowitz, JA Kosmicki, A Damask, D Sharma… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells
via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID …

Genetic variability in COVID-19-related genes in the Brazilian population

R Secolin, TK de Araujo, MC Gonsales… - Human genome …, 2021 - nature.com
SARS-CoV-2 utilizes the angiotensin-converting enzyme 2 (ACE2) receptor and
transmembrane serine protease (TMPRSS2) to infect human lung cells. Previous studies …

Genetic susceptibility of COVID-19: a systematic review of current evidence

SA SeyedAlinaghi, M Mehrtak, M MohsseniPour… - European Journal of …, 2021 - Springer
Introduction While COVID-19 pandemic continues to spread worldwide, researchers have
linked patterns of traits to poor disease outcomes. Risk factors for COVID-19 include asthma …

[HTML][HTML] ACE2 and TMPRSS2 SNPs as Determinants of Susceptibility to, and Severity of, a COVID-19 Infection

S Abdelsattar, ZA Kasemy, SF Ewida… - British Journal of …, 2022 - frontierspartnerships.org
Background: Genetic risk factors may be related to the infectivity and severity of SARS-CoV-
2 infection. Angiotensin-converting enzyme 2 (ACE2) and host transmembrane serine …

SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype

N Yamamoto, Y Ariumi, N Nishida, R Yamamoto… - Gene, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). The relentless spread and pathogenicity of the virus have …