[HTML][HTML] Hippocampal administration of levothyroxine impairs contextual fear memory consolidation in rats
D Yu, H Zhou, L Zou, Y Jiang, X Wu, L Jiang… - Frontiers in Cellular …, 2017 - frontiersin.org
Thyroid hormone (TH) receptors are highly distributed in the hippocampus, which plays a
vital role in memory processes. However, how THs are involved in the different stages of …
vital role in memory processes. However, how THs are involved in the different stages of …
Dorsal hippocampal administration of triiodothyronine enhances long‐term memory for trace cued and delay contextual fear conditioning in rats
L Sui, F Wang, F Liu, J Wang… - Journal of …, 2006 - Wiley Online Library
Thyroid hormones play critical roles in brain maturation and cognitive functions. The present
study investigated the role of thyroid hormone in emotional learning and memory using trace …
study investigated the role of thyroid hormone in emotional learning and memory using trace …
[HTML][HTML] Adult-onset hypothyroidism enhances fear memory and upregulates mineralocorticoid and glucocorticoid receptors in the amygdala
A Montero-Pedrazuela, I Fernández-Lamo, M Alieva… - PLoS …, 2011 - journals.plos.org
Hypothyroidism is the most common hormonal disease in adults, which is frequently
accompanied by learning and memory impairments and emotional disorders. However, the …
accompanied by learning and memory impairments and emotional disorders. However, the …
Evidence for thyroid hormone regulation of amygdala-dependent fear-relevant memory and plasticity
SA Maddox, OY Ponomareva, CE Zaleski… - Molecular …, 2024 - nature.com
The amygdala is an established site for fear memory formation, and clinical studies suggest
involvement of hormone signaling cascades in development of trauma-related disorders …
involvement of hormone signaling cascades in development of trauma-related disorders …
Effects of an acute treatment with L-thyroxine on memory, habituation, danger avoidance, and on Na+, K+-ATPase activity in rat brain
EA Reis-Lunardelli, MR Ramirez… - Current …, 2007 - ingentaconnect.com
Thyroid hormones (THs) have a relevant action on brain development and maintenance. By
using an acute treatment to induce a hyperthyroid animal model, we aimed at investigating …
using an acute treatment to induce a hyperthyroid animal model, we aimed at investigating …
Contribution of Hippocampal 5-HT3 Receptors in Hippocampal Autophagy and Extinction of Conditioned Fear Responses after a Single Prolonged Stress Exposure …
ZM Wu, LH Yang, R Cui, GL Ni, FT Wu… - Cellular and molecular …, 2017 - Springer
One of the hypotheses about the pathogenesis of posttraumatic stress disorder (PTSD) is the
dysfunction of serotonin (5-HT) neurotransmission. While certain 5-HT receptor subtypes are …
dysfunction of serotonin (5-HT) neurotransmission. While certain 5-HT receptor subtypes are …
[HTML][HTML] Effect of Combined Levothyroxine (LT4) and 3-Iodothyronamine (T1AM) Supplementation on Memory and Adult Hippocampal Neurogenesis in a Mouse …
G Rutigliano, A Bertolini, N Grittani… - International Journal of …, 2023 - mdpi.com
Mood alterations, anxiety, and cognitive impairments associated with adult-onset
hypothyroidism often persist despite replacement treatment. In rodent models of …
hypothyroidism often persist despite replacement treatment. In rodent models of …
Thyroidectomy and PTU-induced hypothyroidism: Effect of L-thyroxine on suppression of spatial and non-spatial memory related signaling molecules
K Alzoubi, K Alkadhi - Current Molecular Pharmacology, 2023 - ingentaconnect.com
Background: The calcium/calmodulin protein kinase II (CaMKII) signaling cascade is crucial
for hippocampus-dependent learning and memory. Hypothyroidism impairs hippocampus …
for hippocampus-dependent learning and memory. Hypothyroidism impairs hippocampus …
Hashimoto's thyroiditis induces hippocampus-dependent cognitive alterations by impairing astrocytes in euthyroid mice
N Wang, Y Sun, H Yang, Y Xu, Y Cai, T Liu, Q Xia… - Thyroid, 2021 - liebertpub.com
Background: Although studies have reported an increased risk for cognitive disorders in
Hashimoto's thyroiditis (HT) patients, even in the euthyroid state, the mechanisms involved …
Hashimoto's thyroiditis (HT) patients, even in the euthyroid state, the mechanisms involved …
Levothyroxin restores hypothyroidism‐induced impairment of hippocampus‐dependent learning and memory: Behavioral, electrophysiological, and molecular studies
KH Alzoubi, NZ Gerges, AM Aleisa, KA Alkadhi - Hippocampus, 2009 - Wiley Online Library
Hypothyroidism induces cognitive impairment in experimental animals and patients. Clinical
reports are conflicting about the ability of thyroid hormone replacement therapy to fully …
reports are conflicting about the ability of thyroid hormone replacement therapy to fully …