In this study, we have synthesized and evaluated 18F-JNJ64349311, a tracer with high
affinity for aggregated tau (inhibition constant value, 8 nM) and high (≥ 500×) in vitro …

11C-RO-963, 11C-RO-643, and 18F-RO-948 (previously referred to as 11C-RO6924963,
11C-RO6931643, and 18F-RO6958948, respectively) have been reported as promising PET …

Imaging of neurofibrillary pathology in the brain helps in diagnosing dementia, tracking
disease progression, and evaluating the therapeutic efficacy of antidementia drugs. The …

Purpose Tau deposition is a key pathological feature of Alzheimer's disease (AD) and other
neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined …

Early clinical results of two tau tracers,[18F] T808 and [18F] T807, have recently been
reported. In the present study, the biodistribution, radiometabolite quantification, and …

Tau aggregates and amyloid-β (Aβ) plaques are key histopathologic features in Alzheimer
disease (AD) and are considered targets for therapeutic intervention as well as biomarkers …

18F-T807 is a PET radiotracer developed for imaging tau protein aggregates, which are
implicated in neurologic disorders including Alzheimer disease and traumatic brain injury …

The goal of this paper was to evaluate the in vivo kinetics of the novel tau-specific PET
radioligand 18F-AV-1451 in cognitively healthy control (HC) and Alzheimer disease (AD) …

Purpose 18 F-THK5351 is a novel radiotracer developed for in vivo imaging of tau pathology
in the brain. For the quantitative assessment of tau deposits in the brain, it is important that …

Tau PET imaging has potential for elucidating changes in the deposition of
neuropathological tau aggregates that are occurring during the progression of Alzheimer …